ArticleMitochondrion2007
Interspecies mitochondrial fusion between mouse and human mitochondria is rapid and efficient.
Article in Mitochondrion, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Intercellular Mitochondrial Transfer: Implications in Cardiovascular Health.Circulation research · 2026Review
- Mitochondrial Transfer: From Bench to Bedside.Circulation research · 2026Review
- Article
- Imperial strategy of cancer cells through mitochondrial transfer.Molecular oncology · 2025Review
- Mitochondrial transplantation: adaptive bio-enhancement.Cell death & disease · 2025Article
- Recommendations for mitochondria transfer and transplantation nomenclature and characterization.Nature metabolism · 2025Review
- Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome.Nature metabolism · 2024Article
- Commentary: Can astrocytic mitochondria therapy be used as antioxidant conditioning to protect neurons?Conditioning medicine · 2022Article
- Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma.International journal of molecular sciences · 2022Article
- Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium.Journal of the American College of Cardiology · 2021Article
- Transfer of Xenomitochondria Containing the Entire Mouse Mitochondrial Genome into a Genetically Modified Yeast Expressing Mitochondrial Transcription Factor A.Journal of microbiology and biotechnology · 2020Article
- Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications.Stem cells international · 2017Review
- Mitochondrial Functional Changes Characterization in Young and Senescent Human Adipose Derived MSCs.Frontiers in aging neuroscience · 2016Article
- Internalization of isolated functional mitochondria: involvement of macropinocytosis.Journal of cellular and molecular medicine · 2014Article
- The utility of an isolated mitochondrial fraction in the preparation of liposomes for the specific delivery of bioactives to mitochondria in live mammalian cells.Pharmaceutical research · 2011Article
- Selection by drug resistance proteins located in the mitochondria of mammalian cells.Mitochondrion · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A detailed molecular understanding of mitochondrial fusion and fission in mammalian cells is rapidly emerging. In this report, we demonstrate for the first time cross-species mitochondrial fusion between distantly related species using green and red fluorescent proteins targeted to the mitochondrial matrix. We found that mouse mitochondria were able to efficiently fuse to unmodified mitochondria of human cells and that the contents of the mitochondrial matrix were completely mixed in less than 4h. We also observed that mitochondria from the mtDNA-less (rho(0)) mouse cells can homogeneously fuse to the mitochondria of human cells. We were, however, unable to maintain human mitochondrial DNA in the mouse cells. These results indicate that mitochondrial fusion proteins in mouse and human cells have enough functional homology to mediate efficient cross-species mitochondrial fusion, but mouse nuclear and human mitochondrial genomes have not retained functional compatibility with one another.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.