ArticleDevelopmental biology2007
PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Multiplex DNA fluorescence in situ hybridization to analyze maternal vs. paternal C. elegans chromosomes.Genome biology · 2024Article
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- Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells.Nature communications · 2023Article
- Lamina-Dependent Stretching and Unconventional Chromosome Compartments in Early C. elegans Embryos.Molecular cell · 2020Article
- Developmental Plasticity and Cellular Reprogramming inGenetics · 2019Review
- Distinct functions and temporal regulation of methylated histone H3 during early embryogenesis.Development (Cambridge, England) · 2019Article
- Polycomb and Notch signaling regulate cell proliferation potential duringLife science alliance · 2019Article
- Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation inScience advances · 2018Article
- Genome-wide discovery of active regulatory elements and transcription factor footprints inGenome research · 2017Article
- The Ditylenchus destructor genome provides new insights into the evolution of plant parasitic nematodes.Proceedings. Biological sciences · 2016Article
- Fine-tuning of chromatin composition and Polycomb recruitment by two Mi2 homologues during C. elegans early embryonic development.Epigenetics & chromatin · 2016Article
- PAR-6, but not E-cadherin and β-integrin, is necessary for epithelial polarization in C. elegans.Developmental biology · 2015Article
- TRANSCRIPTION. Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4.Science (New York, N.Y.) · 2015Article
- The conserved role and divergent regulation of foxa, a pan-eumetazoan developmental regulatory gene.Developmental biology · 2011Review
- Locking the genome: nuclear organization and cell fate.Current opinion in genetics & development · 2011Review
- Multiple phenotypes resulting from a mutagenesis screen for pharynx muscle mutations in Caenorhabditis elegans.PloS one · 2011Article
- Article
- Different Mi-2 complexes for various developmental functions in Caenorhabditis elegans.PloS one · 2010Article
- Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA.PLoS genetics · 2010Article
- Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.Molecular endocrinology (Baltimore, Md.) · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A key question in development is how pluripotent progenitors are progressively restricted to acquire specific cell fates. Here we investigate how embryonic blastomeres in C. elegans develop into foregut (pharynx) cells in response to the selector gene PHA-4/FoxA. When pha-4 is removed from pharyngeal precursors, they exhibit two alternative responses. Before late-gastrulation (8E stage), these cells lose their pharyngeal identity and acquire an alternative fate such as ectoderm (Specification stage). After the Specification stage, mutant cells develop into aberrant pharyngeal cells (Morphogenesis/Differentiation stage). Two lines of evidence suggest that the Specification stage depends on transcriptional repression of ectodermal genes by pha-4. First, pha-4 exhibits strong synthetic phenotypes with the B class synMuv gene tam-1 (Tandam Array expression Modifier 1) and with a mediator of transcriptional repression, the NuRD complex (NUcleosome Remodeling and histone Deacetylase). Second, pha-4 associates with the promoter of the ectodermal regulator lin-26 and is required to repress lin-26 expression. We propose that restriction of early blastomeres to the pharyngeal fate depends on both repression of ectodermal genes and activation of pharyngeal genes by PHA-4.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.