ArticleBiochemical and biophysical research communications2007
Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons.
Article in Biochemical and biophysical research communications, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Analysis of variant interactions in families with autism points to genes involved in the development of the central nervous system.PloS one · 2025Article
- Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Age-specific impacts of nicotine and withdrawal on hippocampal neuregulin signalling.The European journal of neuroscience · 2022Article
- Sustained ErbB Activation Causes Demyelination and Hypomyelination by Driving Necroptosis of Mature Oligodendrocytes and Apoptosis of Oligodendrocyte Precursor Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Neuron-autonomous transcriptome changes upon ischemia/reperfusion injury.Scientific reports · 2017Article
- A role for ErbB signaling in the induction of reactive astrogliosis.Cell discovery · 2017Article
- Role of primary afferents in the developmental regulation of motor axon synapse numbers on Renshaw cells.The Journal of comparative neurology · 2016Article
- Calpain-Dependent ErbB4 Cleavage Is Involved in Brain Ischemia-Induced Neuronal Death.Molecular neurobiology · 2016Article
- Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors.Hepatology (Baltimore, Md.) · 2015Article
- A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.The Journal of biological chemistry · 2014Article
- Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex.The Journal of comparative neurology · 2014Article
- Review
- Common themes in PrP signaling: the Src remains the same.Frontiers in cell and developmental biology · 2014Article
- Modulation of A₂a receptor antagonist on D₂ receptor internalization and ERK phosphorylation.Acta pharmacologica Sinica · 2013Article
- Erbin is required for myelination in regenerated axons after injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response.Biochemical and biophysical research communications · 2012Article
- AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Chemistry & biology · 2011Article
- Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia.Molecular psychiatry · 2011Article
- Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Molecular and cellular characterization of Neuregulin-1 type IV isoforms.Journal of neurochemistry · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Neuregulin-1 (NRG1) plays an important role in neural development, synapse formation, and synaptic plasticity by activating ErbB receptor tyrosine kinases. Although ligand-induced endocytosis has been shown to be important for many receptor tyrosine kinases, whether NRG1 signaling depends on ErbB endocytosis remains controversial. Here, we provide evidence that ErbB4, a prominent ErbB protein in the brain, becomes internalized in NRG1-stimulated neurons. The induced ErbB4 endocytosis requires its kinase activity. Remarkably, inhibition of ErbB endocytosis attenuates NRG1-induced activation of Erk and Akt in neurons. These observations indicate a role of ErbB endocytosis in NRG1 signaling in neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.