ArticleBMC genomics2007
Identification of rat lung-specific microRNAs by micoRNA microarray: valuable discoveries for the facilitation of lung research.
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- PTBP1-targeting microRNAs regulate cancer-specific energy metabolism through the modulation of PKM1/M2 splicing.Cancer science · 2021Review
- Integrative p53, micro-RNA and Cathepsin Protease Co-Regulatory Expression Networks in Cancer.Cancers · 2020Review
- Ozone-Induced Vascular Contractility and Pulmonary Injury Are Differentially Impacted by Diets Enriched With Coconut Oil, Fish Oil, and Olive Oil.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Identification of RNA biomarkers for chemical safety screening in mouse embryonic stem cells using RNA deep sequencing analysis.PloS one · 2017Article
- Nuclear Receptor SHP: A Critical Regulator of miRNA and lncRNA Expression and Function.Nuclear receptor research · 2017Article
- The roles of miRNAs as potential biomarkers in lung diseases.European journal of pharmacology · 2016Review
- MiR-196a regulates heme oxygenase-1 by silencing Bach1 in the neonatal mouse lung.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation.International journal of molecular sciences · 2016Review
- Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb.Respiratory research · 2015Article
- Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition.Archives of biochemistry and biophysics · 2015Article
- MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome.BMC medical genomics · 2014Article
- Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells.Genomics, proteomics & bioinformatics · 2014Article
- Article
- miRNA expression atlas in male rat.Scientific data · 2014Article
- Analysis of organ-enriched microRNAs in plasma as an approach to development of Universal Screening Test: feasibility study.Journal of translational medicine · 2013Article
- Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies.Frontiers in cellular neuroscience · 2013Review
- MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Role of microRNAs in lung development and pulmonary diseases.Pulmonary circulation · 2013Review
- miR-375 regulates rat alveolar epithelial cell trans-differentiation by inhibiting Wnt/β-catenin pathway.Nucleic acids research · 2013Article
- MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAn important mechanism for gene regulation utilizes small non-coding RNAs called microRNAs (miRNAs). These small RNAs play important roles in tissue development, cell differentiation and proliferation, lipid and fat metabolism, stem cells, exocytosis, diseases and cancers. To date, relatively little is known about functions of miRNAs in the lung except lung cancer.
resultsIn this study, we utilized a rat miRNA microarray containing 216 miRNA probes, printed in-house, to detect the expression of miRNAs in the rat lung compared to the rat heart, brain, liver, kidney and spleen. Statistical analysis using Significant Analysis of Microarray (SAM) and Tukey Honestly Significant Difference (HSD) revealed 2 miRNAs (miR-195 and miR-200c) expressed specifically in the lung and 9 miRNAs co-expressed in the lung and another organ. 12 selected miRNAs were verified by Northern blot analysis.
conclusionThe identified lung-specific miRNAs from this work will facilitate functional studies of miRNAs during normal physiological and pathophysiological processes of the lung.
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