ArticleBMC neuroscience2007
Kv1.1 null mice have enlarged hippocampus and ventral cortex.
Article in BMC neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Seizures and premature death in mice with targeted Kv1.1 deficiency in corticolimbic circuits.Brain communications · 2025Article
- A personal perspective of the voltage-gated potassium channel studies.Nature structural & molecular biology · 2024Article
- Adenosine deaminase acting on RNA 2 provides neuroprotection by activating Kv1.1 channels in a rat epilepsy model.CytoJournal · 2024Article
- Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice.Cell reports · 2022Article
- KProceedings of the National Academy of Sciences of the United States of America · 2022Article
- KScientific reports · 2021Article
- Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway.eLife · 2021Article
- Kv1.1 deficiency alters repetitive and social behaviors in mice and rescues autistic-like behaviors due to Scn2a haploinsufficiency.Brain and behavior · 2021Article
- Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.Scientific reports · 2021Article
- Spontaneous seizures in Kcna1-null mice lacking voltage-gated Kv1.1 channels activate Fos expression in select limbic circuits.Journal of neurochemistry · 2015Article
- Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers.The Journal of physiology · 2012Article
- Evidence for presence and functional effects of Kv1.1 channels in β-cells: general survey and results from mceph/mceph mice.PloS one · 2011Article
- Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus.Epilepsia · 2007Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMutations in the Shaker-like voltage-gated potassium channel Kv1.1 are known to cause episodic ataxia type 1 and temporal lobe epilepsy. Mice that express a malfunctional, truncated Kv1.1 (BALB/cByJ-Kv1.1mceph/mceph) show a markedly enlarged hippocampus and ventral cortex in adulthood.
resultsTo determine if mice lacking Kv1.1 also develop a brain enlargement similar to mceph/mceph, we transferred Kv1.1 null alleles to the BALB/cByJ background. Hippocampus and ventral cortex was then studied using in vivo 3D-magnetic resonance imaging and volume segmentation in adult Kv1.1 null mice, BALB/cByJ-Kv1.1mceph/mceph, BALB/cByJ-Kv1.1mceph/+, BALB.C3HeB -Kv1.1-/+ and wild type littermates. The Kv1.1 null brains had dramatically enlarged hippocampus and ventral cortex. Mice heterozygous for either the null allele or the mceph allele had normal-sized hippocampus and ventral cortex.
conclusionTotal absence of Kv1.1 can induce excessive overgrowth of hippocampus and ventral cortex in mice with a BALB/cByJ background, while mice with one wild type Kv1.1 allele develop normal-sized brains.
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