ArticleThe Journal of physiology1991
Effect of external Cd2+ and other divalent cations on carbachol-activated non-selective cation channels in guinea-pig ileum.
Article in The Journal of physiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Calcium transients in intramuscular interstitial cells of Cajal of the murine gastric fundus and their regulation by neuroeffector transmission.The Journal of physiology · 2022Article
- Contribution of Rho-kinase to membrane excitability of murine colonic smooth muscle.British journal of pharmacology · 2011Article
- Muscarinic receptor-activated cationic channels in murine ileal myocytes.British journal of pharmacology · 2006Article
- Role of basal extracellular Ca2+ entry during 5-HT-induced vasoconstriction of canine pulmonary arteries.British journal of pharmacology · 2005Article
- Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells.The Journal of physiology · 2004Article
- Comparative capacitative calcium entry mechanisms in canine pulmonary and renal arterial smooth muscle cells.The Journal of physiology · 2002Article
- Voltage-dependent inhibition of the muscarinic cationic current in guinea-pig ileal cells by SK&F 96365.British journal of pharmacology · 2000Article
- Some evidence against the involvement of arachidonic acid in muscarinic suppression of voltage-gated calcium channel current in guinea-pig ileal smooth muscle cells.British journal of pharmacology · 1996Article
- Voltage-dependent calcium currents and cytosolic calcium in equine airway myocytes.The Journal of physiology · 1996Article
- Dual effect of external Ca2+ on noradrenaline-activated cation current in rabbit portal vein smooth muscle cells.The Journal of physiology · 1996Article
- Oxidant stress activates a non-selective cation channel responsible for membrane depolarization in calf vascular endothelial cells.The Journal of physiology · 1996Article
- Two distinct membrane currents activated by cyclopiazonic acid-induced calcium store depletion in single smooth muscle cells of the mouse anococcygeus.British journal of pharmacology · 1996Article
- Quinidine blockade of the carbachol-activated nonselective cationic current in guinea-pig gastric myocytes.British journal of pharmacology · 1995Article
- Effects of divalent cations on muscarinic receptor cationic current in smooth muscle from guinea-pig small intestine.The Journal of physiology · 1995Article
- The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Inactivation of the voltage-dependent Ca2+ channel current in smooth muscle cells isolated from the guinea-pig detrusor.The Journal of physiology · 1993Article
- Pharmacological characterization of muscarinic receptor-activated cation channels in guinea-pig ileum.British journal of pharmacology · 1993Article
- Dual regulation of cation-selective channels by muscarinic and alpha 1-adrenergic receptors in the rabbit portal vein.The Journal of physiology · 1993Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Inhibitory actions of the external divalent cations, Cd2+, Ni2+, Mn2+ and Co2+ on carbachol (CCh)-induced inward current (Ins,ACh) were investigated in caesium aspartate-loaded single longitudinal smooth muscle cells of guinea-pig ileum, using a rapid solution-switching device, under voltage-clamped conditions. 2. Cd2+ (20-1000 microM), when added to the external solution, reduced Ins,ACh rapidly and reversibly. This effect occurred dose dependently, the relationship being adequately described by a Michaelis-Menten equation with a Hill coefficient (n) of 1.0 and a dissociation constant (Kd) of 98 microM. 3. The inhibitory action of Cd2+ was associated neither with agonist concentration (CCh) nor with changes in reversal potential, and was voltage independent. 4. The appearance and removal of the effect of Cd2+ were both rapid (a few hundred milliseconds), in sharp contrast with a relatively slow time course of atropine or CCh action (of the order of seconds). 5. Other divalent cations (Ni2+, Mn2+, Co2+, Mg2+) applied externally also suppressed Ins,ACh, but less potently. The sequence of apparent potency was Cd2+ (98 microM) greater than or equal to Ni2+ (131 microM) much greater than Co2+ (700 microM) greater than or equal to Mn2+ (1000 microM) much greater than Mg2+ (approximately 10 mM). 6. External Ca2+ increased Ins,ACh dose dependently and antagonized the inhibitory effect of Cd2+. However, this effect may not be a simple competition with Cd2+. 7. These results show that external divalent cations strongly modulate Ins,ACh channels, possibly through direct interaction with the channel protein.
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