ArticleDie Naturwissenschaften2007
Potent activity of the lichen antibiotic (+)-usnic acid against clinical isolates of vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus.
Article in Die Naturwissenschaften, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 61 citations in OpenAlex.
- Development, Optimization, and Evaluation of New Gel Formulations with Cyclodextrin Complexes and Volatile Oils with Antimicrobial Activity.Gels (Basel, Switzerland) · 2024Article
- Target identification of usnic acid in bacterial and human cells.RSC chemical biology · 2024Article
- Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing.International journal of molecular sciences · 2023Article
- Effects of the Dibenzofuran, Usnic Acid, on Inhibition of Ocular Biofilm Formation Due to Coagulase-Negative Staphylococci.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Effectiveness of a Self-Decontaminating Coating Containing Usnic Acid in Reducing Environmental Microbial Load in Tertiary-Care Hospitals.International journal of environmental research and public health · 2023Article
- Safety in Rats of a Novel Nasal Spray Formulation for the Prevention of Airborne Viral Infections.Pharmaceutics · 2023Article
- Antimicrobial Effectiveness of an Usnic-Acid-Containing Self-Decontaminating Coating on Underground Metro Surfaces in Athens.Microorganisms · 2022Article
- Characterization of Sunflower Oil Extracts from the LichenMetabolites · 2020Article
- Selective oxidative homo- and cross-coupling of phenols with aerobic catalysts.Journal of the American Chemical Society · 2014Article
- Usnic acid potassium salt: an alternative for the control of Biomphalaria glabrata (Say, 1818).PloS one · 2014Article
- Membrane-damaging potential of natural L-(-)-usnic acid in Staphylococcus aureus.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Eubacterium rangiferina, a novel usnic acid-resistant bacterium from the reindeer rumen.Die Naturwissenschaften · 2008Article
- Review of usnic acid and Usnea barbata toxicity.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviewsReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vancomycin-resistant enterococci (VRE) and methicillin-resistant staphylococci, most notably methicillin-resistant Staphylococcus aureus (MRSA), are serious clinical problems. The antibiotic arsenal available against them is limited, and new mutants worsen the situation. We studied the activity of (+)-usnic acid, an old lichen-derived drug, and its sodium salt against clinical isolates of VRE and MRSA using the agar diffusion and minimal inhibitory concentration (MIC) methods. The acid and, especially, the sodium salt had potent antimicrobial activity against all clinical isolates of VRE and MRSA studied. The MIC values of the sodium salt against VRE strains ranged between 4 and 16 microg/ml (1-day test) and between 4 and 31 microg/ml (2-day test), being below 8 microg/ml for most strains. The salt had potent activity even against those strains that were not inhibited by ampicillin (125 microg/ml), and it never lost its activity after 24 h, in contrast to ampicillin. Thus, in spite of the fact that usnic acid can in some cases cause serious toxicity, it and its salts may be worth considering in clinical practice in cases where other therapies have failed or the microbe is resistant toward other agents.
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