ArticlePloS one2007
Evx2-Hoxd13 intergenic region restricts enhancer association to Hoxd13 promoter.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Identification of genetic associations and functional SNPs of bovine KLF6 gene on milk production traits in Chinese holstein.BMC genomic data · 2023Article
- Vertebrate GAF/ThPOK: emerging functions in chromatin architecture and transcriptional regulation.Cellular and molecular life sciences : CMLS · 2018Review
- A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries).Scientific reports · 2016Article
- DNA methylation and differentiation: HOX genes in muscle cells.Epigenetics & chromatin · 2013Article
- Vertebrate GAGA factor associated insulator elements demarcate homeotic genes in the HOX clusters.Epigenetics & chromatin · 2013Article
- GATA simple sequence repeats function as enhancer blocker boundaries.Nature communications · 2013Article
- Comparison of models for the collinearity of hox genes in the developmental axes of vertebrates.Current genomics · 2012Article
- Secondary DNA structure formation for Hoxb9 promoter and identification of its specific binding protein.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of Hox genes is tightly regulated in spatial and temporal domains. Evx2 is located next to Hoxd13 within 8 kb on the opposite DNA strand. Early in development, the pattern of Hoxd13 expression resembles that of Evx2 in limb and genital buds. After 10 dpc, however, Evx2 begins to be expressed in CNS as well. We analyzed the region responsible for these differences using ES cell techniques, and found that the intergenic region between Evx2 and Hoxd13 behaves as a boundary element that functions differentially in space and time, specifically in the development of limbs, genital bud, and brain. This boundary element comprises a large sequence spanning several kilobases that can be divided into at least two units: a constitutive boundary element, which blocks transcription regulatory influences from the chromosomal environment, and a regulatory element, which controls the function of the constitutive boundary element in time and space.
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