ArticleSexually transmitted infections2007
Molecular typing of Treponema pallidum strains from patients with neurosyphilis in Pretoria, South Africa.
Article in Sexually transmitted infections, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Global research trends in neurosyphilis: a bibliometric analysis from 2010 to 2024.Frontiers in immunology · 2025Pooled it
- Neurosyphilis in Africa: A systematic review.PLoS neglected tropical diseases · 2017Pooled it
- Molecular typing of Treponema pallidum: a systematic review and meta-analysis.PLoS neglected tropical diseases · 2011Pooled it
- Update on syphilis diagnostics.Current opinion in infectious diseases · 2025Review
- Molecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections.Clinical microbiology reviews · 2024Review
- Neurosyphilis: insights into its pathogenesis, susceptibility, diagnosis, treatment, and prevention.Frontiers in neurology · 2023Review
- High-throughput nanopore sequencing ofFrontiers in microbiology · 2022Article
- Molecular and Direct Detection Tests for Treponema pallidum Subspecies pallidum: A Review of the Literature, 1964-2017.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Review
- The molecular epidemiology of Treponema pallidum subspecies pallidum.Sexual health · 2015Article
- Comparison of CDC and sequence-based molecular typing of syphilis treponemes: tpr and arp loci are variable in multiple samples from the same patient.BMC microbiology · 2013Article
- Molecular typing of Treponema pallidum: a 5-year surveillance in Shanghai, China.Journal of clinical microbiology · 2012Article
- Evaluation of macrolide resistance and enhanced molecular typing of Treponema pallidum in patients with syphilis in Taiwan: a prospective multicenter study.Journal of clinical microbiology · 2012Article
- Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012Review
- Syphilis: using modern approaches to understand an old disease.The Journal of clinical investigation · 2011Review
- Enhanced molecular typing of treponema pallidum: geographical distribution of strain types and association with neurosyphilis.The Journal of infectious diseases · 2010Article
- Secondary syphilis in cali, Colombia: new concepts in disease pathogenesis.PLoS neglected tropical diseases · 2010Article
- Molecular subtyping of Treponema pallidum subsp. pallidum in Lisbon, Portugal.Journal of clinical microbiology · 2009Article
- Molecular characterization of syphilis in patients in Canada: azithromycin resistance and detection of Treponema pallidum DNA in whole-blood samples versus ulcerative swabs.Journal of clinical microbiology · 2009Article
- Molecular typing of treponema pallidum clinical strains from Lisbon, Portugal.Journal of clinical microbiology · 2008Article
- Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays.BMC microbiology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo evaluate the molecular typing system for Treponema pallidum using cerebrospinal fluid (CSF) specimens obtained from patients with neurosyphilis in Pretoria, South Africa.
methodsCSF specimens were collected from 32 men and 18 women with suspected late neurosyphilis. Typing of T pallidum involved PCR amplification and restriction analysis of the tprE, G and J genes and determination of the number of 60 base pair tandem repeats within the arp gene by PCR amplification.
resultsOf 13 typeable specimens, 4 strain types were identified: 2i, 3e, 14a and 17e. Subtype 14a was identified in 7 specimens (53.8%), subtype 3e in 4 specimens (30.7%) and subtypes 17e and 2i in 1 specimen (7.6%) each.
conclusionsThis study shows that the typing system can be applied to specimens which may contain low numbers of spirochaetes such as CSF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.