ArticleJournal of neuroendocrinology2007
Cells in behaviourally relevant brain regions coexpress nuclear receptor coactivators and ovarian steroid receptors.
Article in Journal of neuroendocrinology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Nuclear receptor coactivators: regulators of steroid action in brain and behaviour.Journal of neuroendocrinology · 2013Review
- Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Convergence of multiple mechanisms of steroid hormone action.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2012Review
- Neural progestin receptors and female sexual behavior.Neuroendocrinology · 2012Review
- Steroid receptor coactivator 2 modulates steroid-dependent male sexual behavior and neuroplasticity in Japanese quail (Coturnix japonica).Journal of neurochemistry · 2011Article
- Nuclear receptor coactivators are coexpressed with steroid receptors and regulated by estradiol in mouse brain.Neuroendocrinology · 2011Article
- Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors.Neuroscience · 2010Article
- Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.Nuclear receptor signaling · 2009Review
- Modulation of steroid action in the central and peripheral nervous systems by nuclear receptor coactivators.Psychoneuroendocrinology · 2009Review
- Who's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior.Frontiers in neuroendocrinology · 2009Review
- Nuclear receptor coactivators: essential players for steroid hormone action in the brain and in behaviour.Journal of neuroendocrinology · 2009Review
- Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes.Endocrinology · 2008Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Oestradiol and progesterone act in the brain to elicit profound effects on behaviour and physiology. One physiological function of oestradiol is the induction of progesterone receptor (PR) expression in a variety of behaviourally relevant brain regions, including the ventromedial nucleus of the hypothalamus (VMN), the medial preoptic nucleus of the preoptic area (MPOA), the arcuate nucleus (ARC) and the medial central grey (MCG). Ligand-dependent transcriptional activity of steroid receptors, including oestrogen receptors (ER) and Pr, is dramatically influenced by nuclear receptor coactivators. In previous studies, we have found that two of these nuclear receptor coactivators, steroid receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), are important in ER-mediated induction of PR in the VMN and in steroid-dependent behaviours. For nuclear receptor coactivators to function in hormone-dependent transcription in the brain and regulate behaviour, both receptor and coactivator must be expressed in the same cell. In the present study, we used a dual-label immunohistochemical technique to investigate if individual cells in behaviourally relevant brain regions coexpress nuclear receptor coactivators and steroid receptors. Confocal analysis revealed that in oestrogen-primed rats, most of the E-induced PR cells in the VMN (89.6%), MPOA (63%), ARC (82.6%), and many in the MCG (39%), also express SRC-1. In addition, the majority of the cells containing E-induced PR in the VMN (78.3%), MPOA (83.1%), ARC (83.6%), and MCG (60%) also express CBP. These results, taken together with the findings that virtually all oestradiol-induced PR containing cells in the brain express ER, suggest that these neurones represent sites of functional interaction of nuclear receptor coactivators with ovarian steroid receptors in the brain. The present findings provide neuroanatomical evidence that nuclear receptor coactivators are integral in mediating steroid hormone action in behaviourally relevant brain regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.