ArticleDifferentiation; research in biological diversity2007
All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas.
Article in Differentiation; research in biological diversity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Tridax procumbens promotes apoptosis and suppresses markers of proliferation, growth, and metastasis in pancreatic ductal adenocarcinoma cells.BMC complementary medicine and therapies · 2026Article
- From iPSCs to Pancreatic β Cells: Unveiling Molecular Pathways and Enhancements with Vitamin C and Retinoic Acid in Diabetes Research.International journal of molecular sciences · 2024Article
- Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA).Stem cell reviews and reports · 2021Article
- Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Retinoids in the pancreas.Hepatobiliary surgery and nutrition · 2016Review
- Ectopic Ptf1a expression in murine ESCs potentiates endocrine differentiation and models pancreas development in vitro.Stem cells (Dayton, Ohio) · 2014Article
- Aldehyde dehydrogenase 1 activity in the developing human pancreas modulates retinoic acid signalling in mediating islet differentiation and survival.Diabetologia · 2014Article
- Directed differentiation of embryonic stem cells allows exploration of novel transcription factor genes for pancreas development.Stem cell reviews and reports · 2012Article
- Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells.Journal of molecular medicine (Berlin, Germany) · 2012Review
- Retinoic acid synthesis and functions in early embryonic development.Cell & bioscience · 2012Article
- Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish.PLoS biology · 2008Article
- Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells.PloS one · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent evidence has shown that retinoic acid (RA) signalling is required for early pancreatic development in zebrafish and frog but its role in later development in mammals is less clear cut. In the present study, we determined the effects of RA on the differentiation of the mouse embryonic pancreas. Addition of all-trans retinoic acid (atRA) to embryonic pancreatic cultures induced a number of changes. Branching morphogenesis and exocrine differentiation were suppressed and there was premature formation of endocrine cell clusters (although the total area of beta cells was not different in control and atRA-treated buds). We investigated the mechanism of these changes and found that the premature formation of beta cells was associated with the early expression of high-level Pdx1 in the endocrine cell clusters. In contrast, the suppressive effect of RA on exocrine differentiation may be due to a combination of two mechanisms (i) up-regulation of the extracellular matrix component laminin and (ii) enhancement of apoptosis. We also demonstrate that addition of fibroblast growth factor (FGF)-10 is able to partially prevent apoptosis and rescue exocrine differentiation and branching morphogenesis in atRA-treated cultures but not in mice lacking the FGF receptor 2-IIIb, suggesting the effects of FGF-10 are mediated through this receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.