ArticleJournal of clinical immunology2007
Serological and clinical comparison of children and adults with anti-endomysial antibodies.
Article in Journal of clinical immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Prevalence of coeliac disease in patients with systemic lupus erythematosus: a systematic review and meta-analysis.Lupus science & medicine · 2024Pooled it
- Staining patterns of autoantibodies in indirect immunofluorescence for autoimmune diseases of the digestive system: morphological characteristics and clinical significance.Frontiers in immunology · 2026Review
- Reliability and reproducibility of antinuclear antibody testing in pediatric rheumatology practice.Frontiers in medicine · 2022Review
- Celiac Disease: A Common Unrecognized Health Problem with a Very Delayed Diagnosis.Medicina (Kaunas, Lithuania) · 2019Article
- Age-related differences in celiac disease: Specific characteristics of adult presentation.World journal of gastrointestinal pharmacology and therapeutics · 2015Review
- Pediatric and adult celiac disease: similarities and differences.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2013Review
- Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity.Neuromuscular disorders : NMD · 2010Article
- Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma.BMC immunology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared serological and clinical presentation of 38 adults (5 males, 33 females) and 37 children (15 boys, 22 girls) with anti-endomysial antibodies (AEA).AEA, antinuclear (ANA), anti-parietal (APA), anti-thyroid microsomal (ATMA), anti-thyreoglobulin (ATGA), anti-smooth muscle (SMA) and anti-mitochondrial (AMA) antibodies were detected by IIF. Anti-tissue transglutaminase (tTG), anti-extractable nuclear antigens (ENA) and anti-actin (AAA) antibodies were studied by ELISA. There were no differences in frequency of ANA, APA, ATGA, SMA, AMA and AAA in children and adults. ATMA (p < 0.001) and anti-ENA (p < 0.05) positivity were more frequently found in adults. Anti-Ro/SSA had 7/38 adults and 1/37 children (p < 0.05). Adults had more frequently silent form of celiac disease associated with autoimmune diseases (p < 0.001). We are the first to demonstrate that in spite of no difference in ANA positivity in adults and children, ANA in adults more frequently target ENA, especially Ro/SSA antigen. The reason for this ANA specificity could be the longer gluten exposure in adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.