ArticleMolecular and cellular biochemistry2007
Degenerative and apoptotic events at retinal and optic nerve level after experimental induction of ocular hypertension.
Article in Molecular and cellular biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Strategies to Reduce Oxidative Stress in Glaucoma Patients.Current neuropharmacology · 2018Review
- Cellular stress response, redox status, and vitagenes in glaucoma: a systemic oxidant disorder linked to Alzheimer's disease.Frontiers in pharmacology · 2014Article
- The cell stress machinery and retinal degeneration.FEBS letters · 2013Review
- The ubiquitin-proteasome system in retinal health and disease.Molecular neurobiology · 2013Review
- Article
- Degenerative effects in rat eyes after experimental ocular hypertension.European journal of histochemistry : EJH · 2012Article
- Mitochondrial dysfunction in retinal diseases.Current eye research · 2011Review
- Carnitine reduces the lipoperoxidative damage of the membrane and apoptosis after induction of cell stress in experimental glaucoma.Cell death & disease · 2010Article
- Mechanisms of retinal ganglion cell injury and defense in glaucoma.Experimental eye research · 2010Review
- Differential cytotoxicity of MEX: a component of Neem oil whose action is exerted at the cell membrane level.Molecules (Basel, Switzerland) · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ocular hypertension is a symptom of a glaucomatous condition characterized by a severe vision decrease. Blindness caused by the apoptotic death of the retinal ganglion cells and of the astrocytes of the optic nerve may eventually result. Experimental hypertension was induced by inoculation of methylcellulose in the anterior chamber. Chromatin staining, TUNEL assay, and inter-nucleosomal DNA fragmentation observed in retina and optic nerve strongly suggest that hypertension causes apoptosis. Immunolocalization of the fibrillary acidic glial protein, specific of cell stress, and caspase-3 in the same tissues, further support this mode of cell death. Activation of the ubiquitin dependent proteolytic system was also observed. Protection from apoptosis exerted by administration of the peroxide scavenger trolox, suggests that the apoptotic pathway is activated by an oxidative stress. The data presented here show that the experimental hypertensive insult induces degenerative and apoptotic events comparable to those observed in human glaucoma.
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Registered trials
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