ArticleInternational journal of colorectal disease2007
The frequency of C3435T MDR1 gene polymorphism in Iranian patients with ulcerative colitis.
Article in International journal of colorectal disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Pooled it
- CTLA-4 and MDR1 polymorphisms increase the risk for ulcerative colitis: A meta-analysis.World journal of gastroenterology · 2015Pooled it
- The roles of ABCB1/P-glycoprotein drug transporters in regulating gut microbes and inflammation: insights from animal models, old and new.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Pharmacogenetics of tamoxifen therapy in Asian populations: from genetic polymorphism to clinical outcomes.European journal of clinical pharmacology · 2021Review
- Lack of association between VEGF -2578C/A polymorphism and risk of colorectal cancer in an Iranian population.Gastroenterology and hepatology from bed to bench · 2020Article
- Evaluation of CXCR1 as a possible diagnostic biomarker in acute appendicitis.Gastroenterology and hepatology from bed to bench · 2020Article
- Introducing GATA3 as a prominent player in Crohn's disease.Gastroenterology and hepatology from bed to bench · 2020Article
- Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology.Gastroenterology and hepatology from bed to bench · 2019Article
- Contribution of NOTCH signaling pathway along with TNF-α in the intestinal inflammation of ulcerative colitis.Gastroenterology and hepatology from bed to bench · 2019Article
- MDR1 gene polymorphisms are associated with ulcerative colitis in a cohort of Serbian patients with inflammatory bowel disease.PloS one · 2018Article
- ABCB1 3435C>T and 2677G>T/A polymorphisms in Polish and Bosnian patients with Crohn's disease - A preliminary report.Bosnian journal of basic medical sciences · 2017Article
- P-glycoprotein multidrug transporter in inflammatory bowel diseases: More questions than answers.World journal of gastroenterology · 2017Article
- Diabetes mellitus and hypertension increase the risk of colorectal cancer mortality; a robust Bayesian adjustment analysis.Gastroenterology and hepatology from bed to bench · 2017Article
- Detailed analysis of total colectomy on health-related quality of life in adult patients with ulcerative colitis.Gastroenterology and hepatology from bed to bench · 2017Article
- Evaluation of IL-17B and IL-17F mRNA expression in peripheral blood mononuclear cells and association with clinical outcome of IBD patients.Gastroenterology and hepatology from bed to bench · 2017Article
- Common and differential genetically pathways between ulcerative colitis and colon adenocarcinoma.Gastroenterology and hepatology from bed to bench · 2017Article
- Evaluation of involved proteins in colon adenocarcinoma: an interactome analysis.Gastroenterology and hepatology from bed to bench · 2017Article
- Interleukin-21 rs2055979 and Interleukin-21 receptor rs3093390 genetic variants and hepatitis C virus chronic infection.Gastroenterology and hepatology from bed to bench · 2017Article
- Determination of Vitamin D Serum Levels and Status of the C3435T Polymorphism of Multidrug Resistance 1 Gene in Southeastern Iranian Patients with Ulcerative Colitis.Middle East journal of digestive diseases · 2015Article
- Effect of vitamin D3 supplementation on TNF-α serum level and disease activity index in Iranian IBD patients.Gastroenterology and hepatology from bed to bench · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe MDR1 (multidrug resistance) gene, located on chromosome 7, is in one of the inflammatory bowel disease susceptibility loci. It produces P-glycoprotein, a transmembrane efflux pump, transferring drugs and toxins from intracellular to extracellular domains. In the human gastrointestinal (GI) tract, P-glycoprotein is found in high concentrations on the epithelial cells of the colon and small intestine. MDR1 gene polymorphisms such as C3435T are associated with lower P-glycoprotein expression, and thus it is suggested to have an association with ulcerative colitis. We tried to determine the frequency of C3435T polymorphism of the MDR1 gene in Iranian patients with ulcerative colitis and to compare it with a healthy control population. MATERIALS AND
methodsIn this case-control-designed study, 300 unrelated ulcerative colitis patients and 300 sex-and-age-matched healthy controls were enrolled. They were visited at a tertiary center during a 2-year period (2003-2005). DNA of patients and controls was amplified by polymerase chain reaction with specific primers, and C3435T polymorphism was detected by the restriction fragment length polymorphism method.
resultsThe frequency of the 3435T allele was significantly higher in ulcerative colitis patients compared to the controls (p < 0.001). The frequency of homozygote T/T and heterozygote C/T genotypes were also significantly higher in Iranian patients with ulcerative colitis (p = 0.044 and 0.041, respectively).
conclusionThis study suggests that C3435T polymorphism of the MDR1 gene has an association with ulcerative colitis in Iranian population as previously reported in western countries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.