ArticleMolecular vision2007
Dual gene therapy with extracellular superoxide dismutase and catalase attenuates experimental optic neuritis.
Article in Molecular vision, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Review
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- Phanerochaete chrysosporium as a model organism to assess the toxicity of municipal landfill leachate from Elazığ, Turkey.Environmental science and pollution research international · 2019Article
- SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis.Investigative ophthalmology & visual science · 2018Article
- Oxidative Stress and Neurobiology of Demyelination.Molecular neurobiology · 2016Review
- Complex I subunit gene therapy with NDUFA6 ameliorates neurodegeneration in EAE.Investigative ophthalmology & visual science · 2015Article
- Cerebrospinal fluid and plasma oxidative stress biomarkers in different clinical phenotypes of neuroinflammatory acute attacks. Conceptual accession: from fundamental to clinic.Cellular and molecular neurobiology · 2013Article
- Aging decreases antioxidant effects and increases lipid peroxidation in the Apolipoprotein E deficient mouse.Journal of clinical biochemistry and nutrition · 2013Article
- Mitochondria-targeted antiaging gene therapy with adeno-associated viral vectors.Methods in molecular biology (Clifton, N.J.) · 2013Article
- β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.EMBO molecular medicine · 2012Article
- Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging.Journal of clinical & experimental pathology · 2012Article
- A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics.Cell death & disease · 2011Article
- Analysis of the pathogenesis of experimental autoimmune optic neuritis.Journal of biomedicine & biotechnology · 2011Article
- Regulation of extracellular-superoxide dismutase in rat retina pericytes.Redox report : communications in free radical research · 2010Article
- Channelrhodopsins provide a breakthrough insight into strategies for curing blindness.Journal of genetics · 2009Review
- Identification of direct regulatory targets of the transcription factor Sox10 based on function and conservation.BMC genomics · 2008Article
- Inflammatory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis.Experimental eye research · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo ameliorate experimental optic neuritis by combining scavenging of superoxide by germ line increases in the extracellular superoxide dismutase (ECSOD) and hydrogen peroxide by viral-mediated gene transfer of the human catalase gene.
methodsThe human catalase gene inserted into recombinant adeno-associated virus (rAAV) was injected into the right eyes of transgenic mice overexpressing human ECSOD and wild-type littermates. Animals were simultaneously sensitized for experimental autoimmune encephalomyelitis (EAE) and then sacrificed one month later. The effects of antioxidant genes (ECSOD and catalase) on the histologic lesions of EAE were measured by computerized analysis of myelin area, optic disc area, extent of the cellular infiltrate, cerium derived H(2)O(2) reaction product and extravasation of serum albumin detected by immunogold.
resultsCombined scavenging of H(2)O(2) and superoxide with ECSOD and catalase suppressed demyelination by 72%, 54% due to catalase, and 19% due to ECSOD. Disruption of the blood-brain barrier was reduced 63% by the combined effects of catalase and ECSOD, 35% due to catalase and 29% due to ECSOD.
conclusionsTransgene modulation of antioxidant enzyme defenses against both superoxide and its metabolite H(2)O(2) provide a substantial suppressive effect against EAE in the optic nerve that may be a new therapeutic strategy for suppression of optic neuritis and multiple sclerosis.
Indexed as
Identifiers
17242675PMC2504532W103320257What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.