ArticleProceedings of the National Academy of Sciences of the United States of America2007
Chromosome-wide linkage disequilibrium as a consequence of meiotic drive.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 143 citations in OpenAlex.
- No evidence of sex-ratio meiotic drive associated with the X-linked In(1)Be inversion in Drosophila melanogaster.G3 (Bethesda, Md.) · 2026Article
- The highly heterozygous European amphioxus (Branchiostoma lanceolatum) at the edge of panmixia.PLoS genetics · 2026Article
- Single-cell consequences of X-linked meiotic drive in stalk-eyed flies.PLoS genetics · 2025Article
- Novel stressors and trait variation determine X-linked meiotic drive frequency.Proceedings. Biological sciences · 2025Article
- The metabolic costs of meiotic drive.Proceedings. Biological sciences · 2025Article
- Intrinsically weak sex chromosome drive through sequential asymmetric meiosis.Science advances · 2025Article
- A selfish supergene causes meiotic drive through both sexes inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Testing the evolutionary theory of inversion polymorphisms in the yellow monkeyflower (Mimulus guttatus).Nature communications · 2024Article
- Non-Mendelian transmission of X chromosomes: mechanisms and impact on sex ratios and population dynamics in different breeding systems.Biochemical Society transactions · 2024Review
- Inter-clonal competition over queen succession imposes a cost of parthenogenesis on termite colonies.Proceedings. Biological sciences · 2024Article
- Review
- Genetic conflict and the origin of multigene families: implications for sex chromosome evolution.Proceedings. Biological sciences · 2023Review
- Impacts of Sex Ratio Meiotic Drive on Genome Structure and Function in a Stalk-Eyed Fly.Genome biology and evolution · 2023Article
- Article
- Meiotic drive is associated with sexual incompatibility in Neurospora.Evolution; international journal of organic evolution · 2022Article
- TheeLife · 2022Article
- Supergene potential of a selfish centromere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Sheltering of deleterious mutations explains the stepwise extension of recombination suppression on sex chromosomes and other supergenes.PLoS biology · 2022Article
- Epistatic selection on a selfisheLife · 2022Article
- Novel patterns of expression and recruitment of new genes on theProceedings. Biological sciences · 2022Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptation by natural selection proceeds most efficiently when alleles compete solely on the basis of their effects on the survival and reproduction of their carriers. A major condition for this is equal Mendelian segregation, but meiotic drive can short-circuit this process. The evolution of drive often involves multiple, interacting genetic components, together with enhancers and suppressors of drive. Chromosomal inversions that suppress crossing over are also frequently associated with drive systems. This study investigates the effects of these processes on patterns of molecular evolution in the fly Drosophila recens, which is polymorphic for a driving X chromosome (X(D)). Whereas standard wild-type chromosomes exhibit high levels of polymorphism at multiple loci, all of the X(D) chromosomes effectively carry a single multilocus haplotype that spans at least 130 cM. The X(D) is associated with a complex set of inversions that completely suppresses recombination between the standard wild-type chromosome and X(D) in heterozygous females, which maintain nonrandom associations among loci that presumably interact epistatically for the expression of drive. The long-term costs of foregoing recombination may be substantial; in combination with its low equilibrium frequency, this makes the X(D) chromosome susceptible to the accumulation of deleterious mutations. Consistent with this, X(D) chromosomes are apparently fixed for a recessive mutation that causes female sterility. Thus, the X(D) in D. recens appears to be in chromosome-wide linkage disequilibrium and in the early stages of mutational degradation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.