ArticleProceedings of the National Academy of Sciences of the United States of America2007
Distortion product otoacoustic emissions measured as vibration on the eardrum of human subjects.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 57 citations in OpenAlex.
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- Criticality and chaos in auditory and vestibular sensing.Scientific reports · 2024Article
- Review of chaos in hair-cell dynamics.Frontiers in neurology · 2024Review
- A minimal physics-based model for musical perception.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Age-related degradation of tectorial membrane dynamics with loss of CEACAM16.Biophysical journal · 2021Article
- Review
- Rapid imaging of tympanic membrane vibrations in humans.Biomedical optics express · 2020Article
- Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system.Biomedical optics express · 2019Article
- A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ.Nature communications · 2018Article
- Homeostatic enhancement of sensory transduction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Reticular lamina and basilar membrane vibrations in living mouse cochleae.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Identification of Bifurcations from Observations of Noisy Biological Oscillators.Biophysical journal · 2016Article
- Mechanical basis of otoacoustic emissions in tympanal hearing organs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
- An overview of wideband immittance measurements techniques and terminology: you say absorbance, I say reflectance.Ear and hearing · 2013Review
- Effects of cochlear loading on the motility of active outer hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Review
- Measurement of conductive hearing loss in mice.Hearing research · 2010Article
- Comment on "When an air-bone gap is not a sign of a middle-ear conductive loss" By Sohmer et al.Ear and hearing · 2009Article
- Clinical utility of laser-Doppler vibrometer measurements in live normal and pathologic human ears.Ear and hearing · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has previously not been possible to measure eardrum vibration of human subjects in the region of auditory threshold. It is proposed that such measurements should provide information about the status of the mechanical amplifier in the cochlea. It is this amplifier that is responsible for our extraordinary hearing sensitivity. Here, we present results from a laser Doppler vibrometer that we designed to noninvasively probe cochlear mechanics near auditory threshold. This device enables picometer-sized vibration measurements of the human eardrum in vivo. With this sensitivity, we found the eardrum frequency response to be linear down to at least a 20-dB sound pressure level (SPL). Nonlinear cochlear amplification was evaluated with the cubic distortion product of the otoacoustic emissions (DPOAEs) in response to sound stimulation with two tones. DPOAEs originate from mechanical nonlinearity in the cochlea. For stimulus frequencies, f1 and f2, with f2/f1 = 1.2 and f2 = 4-9.5 kHz, and intensities L1 and L2, with L1 = 0.4L(2) + 39 dB and L2 = 20-65 dB SPL, the DPOAE displacement amplitudes were no more than 8 pm across subjects (n = 20), with hearing loss up to 16 dB. DPOAE vibration was nonlinearly dependent on vibration at f2. The dependence allowed the hearing threshold to be estimated objectively with high accuracy; the standard deviation of the threshold estimate was only 8.6 dB SPL. This device promises to be a powerful tool for differentially characterizing the mechanical condition of the cochlea and middle ear with high accuracy.
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