ArticleProceedings of the National Academy of Sciences of the United States of America2007
RNaseE and the other constituents of the RNA degradosome are components of the bacterial cytoskeleton.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 123 citations in OpenAlex.
- Identification of proteins interacting with the N-terminal half of endoribonuclease RNase E inRNA biology · 2026Article
- Distinct Spatial Organisation of Rho and RNA Polymerase in Salmonella Cells.Molecular microbiology · 2026Article
- Critical functions and key interactions mediated by the RNase E scaffolding domain in Pseudomonas aeruginosa.PLoS genetics · 2025Article
- Hunting the Cell CycleLife (Basel, Switzerland) · 2024Article
- Proteomic composition of eukaryotic and bacterial RNA decay condensates suggests convergent evolution.Current opinion in microbiology · 2024Review
- MinD-RNase E interplay controls localization of polar mRNAs in E. coli.The EMBO journal · 2024Article
- Visualizing the invisible: novel approaches to visualizing bacterial proteins and host-pathogen interactions.Frontiers in bioengineering and biotechnology · 2024Review
- Unraveling Membrane Perturbations Caused by the Bacterial Riboregulator Hfq.International journal of molecular sciences · 2022Article
- Article
- Generation of Bacterial Diversity by Segregation of DNA Strands.Frontiers in microbiology · 2021Article
- Phase-separated bacterial ribonucleoprotein bodies organize mRNA decay.Wiley interdisciplinary reviews. RNA · 2020Review
- Mechanical property of the helical configuration for a twisted intrinsically straight biopolymer.European biophysics journal : EBJ · 2019Article
- Successive Paradigm Shifts in the Bacterial Cell Cycle and Related Subjects.Life (Basel, Switzerland) · 2019Article
- Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens.Biochemistry · 2019Article
- Examining the Protein Interactome and Subcellular Localization of RNase J2 Complexes inFrontiers in microbiology · 2019Article
- α-Proteobacterial RNA Degradosomes Assemble Liquid-Liquid Phase-Separated RNP Bodies.Molecular cell · 2018Article
- RNA Localization in Bacteria.Microbiology spectrum · 2018Review
- Polar localization of MreB actin is inhibited by anionic phospholipids in the rod-shaped bacterium Escherichia coli.Current genetics · 2017Review
- The Structure and Function of the Gram-Positive Bacterial RNA Degradosome.Frontiers in microbiology · 2017Review
- Quantitative Proteomics Analysis Reveals the Min System of Escherichia coli Modulates Reversible Protein Association with the Inner Membrane.Molecular & cellular proteomics : MCP · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
RNaseE is the main component of the RNA degradosome of Escherichia coli, which plays an essential role in RNA processing and decay. Localization studies showed that RNaseE and the other known degradosome components (RNA helicase B, polynucleotide phosphorylase, and enolase) are organized as helical filamentous structures that coil around the length of the cell. These resemble the helical structures formed by the MreB and MinD cytoskeletal proteins. Formation of the RNaseE cytoskeletal-like structure requires an internal domain of the protein that does not include the domains required for any of its known interactions or the minimal domain required for endonuclease activity. We conclude that the constituents of the RNA degradosome are components of the E. coli cytoskeleton, either assembled as a primary cytoskeletal structure or secondarily associated with another underlying cytoskeletal element. This suggests a previously unrecognized role for the bacterial cytoskeleton, providing a mechanism to compartmentalize proteins that act on cytoplasmic components, as exemplified by the RNA processing and degradative activities of the degradosome, to regulate their access to important cellular substrates.
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