ArticleThe Journal of experimental medicine2007
Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- From Antibody Repertoires to Cell-Cell Interactions to Molecular Networks: Bridging Scales in the Germinal Center.Frontiers in immunology · 2022Review
- The Role of APOBECs in Viral Replication.Microorganisms · 2020Review
- Signaling control of antibody isotype switching.Advances in immunology · 2019Review
- TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers.Cellular & molecular immunology · 2016Article
- Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity.Nature reviews. Immunology · 2016Review
- APOBECs and virus restriction.Virology · 2015Review
- AID expression in peripheral blood of children living in a malaria holoendemic region is associated with changes in B cell subsets and Epstein-Barr virus.International journal of cancer · 2015Article
- Epigenetic function of activation-induced cytidine deaminase and its link to lymphomagenesis.Frontiers in immunology · 2014Review
- Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma.PloS one · 2013Article
- Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis.Cancer science · 2012Review
- Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype.Journal of leukocyte biology · 2011Article
- Activation of the NF-kappaB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers.Nature immunology · 2010Article
- The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells.The Journal of experimental medicine · 2010Article
- The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia.Cancer cell · 2009Article
- Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Article
- Expression of infectious murine leukemia viruses by RAW264.7 cells, a potential complication for studies with a widely used mouse macrophage cell line.Retrovirology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Activation-induced cytidine deaminase (AID) is expressed in germinal centers of lymphoid organs during immunoglobulin diversification, in bone marrow B cells after infection with Abelson murine leukemia retrovirus (Ab-MLV), and in human B cells after infection by hepatitis C virus. To understand how viruses signal AID induction in the host we asked whether the AID response was abrogated in cells deficient in the interferon pathway or in signaling via the Toll-like receptors. Here we show that AID is not an interferon responsive gene and abrogation of Toll-like receptor signaling does not diminish the AID response. However, we found that NF-kappaB was required for expression of virally induced AID. Since NF-kappaB binds and activates the AID promoter, these results mechanistically link viral infection with AID transcription. Thus, induction of AID by viruses could be the result of several signaling pathways that culminate in NF-kappaB activation, underscoring the versatility of this host defense program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.