ArticleThe Journal of cell biology2007
SecY alterations that impair membrane protein folding and generate a membrane stress.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Functional mapping and engineering of the Sec translocon unlocked by a cell-free system.Science advances · 2026Article
- The divergentMicrobiology (Reading, England) · 2026Article
- Simple But Efficacious Enrichment of Integral Membrane Proteins and Their Interactions for In-Depth Membrane Proteomics.Molecular & cellular proteomics : MCP · 2022Article
- The Dynamic SecYEG Translocon.Frontiers in molecular biosciences · 2021Review
- GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli.Microbial cell factories · 2019Article
- Export of a Vibrio parahaemolyticus toxin by the Sec and type III secretion machineries in tandem.Nature microbiology · 2019Article
- Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis.The Journal of biological chemistry · 2018Article
- A photo-cross-linking approach to monitor folding and assembly of newly synthesized proteins in a living cell.The Journal of biological chemistry · 2018Article
- Major Tom to Ground Control: How Lipoproteins Communicate Extracytoplasmic Stress to the Decision Center of the Cell.Journal of bacteriology · 2017Review
- Biochemical and structural insights into intramembrane metalloprotease mechanisms.Biochimica et biophysica acta · 2013Review
- Heat shock transcription factor σ32 co-opts the signal recognition particle to regulate protein homeostasis in E. coli.PLoS biology · 2013Article
- YidC protein, a molecular chaperone for LacY protein folding via the SecYEG protein machinery.The Journal of biological chemistry · 2013Article
- The Cpx stress response confers resistance to some, but not all, bactericidal antibiotics.Journal of bacteriology · 2013Article
- Multi-copy genes that enhance the yield of mammalian G protein-coupled receptors in Escherichia coli.Metabolic engineering · 2012Article
- Contribution of SecDF to Staphylococcus aureus resistance and expression of virulence factors.BMC microbiology · 2011Article
- Activators of the glutamate-dependent acid resistance system alleviate deleterious effects of YidC depletion in Escherichia coli.Journal of bacteriology · 2011Article
- Consequences of depletion of the signal recognition particle in Escherichia coli.The Journal of biological chemistry · 2011Article
- YidC is involved in the biogenesis of the secreted autotransporter hemoglobin protease.The Journal of biological chemistry · 2010Article
- Simple genetic selection protocol for isolation of overexpressed genes that enhance accumulation of membrane-integrated human G protein-coupled receptors in Escherichia coli.Applied and environmental microbiology · 2010Article
- Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
We report on a class of Escherichia coli SecY mutants that impair membrane protein folding. The mutants also up-regulate the Cpx/sigma(E) stress response pathways. Similar stress induction was also observed in response to a YidC defect in membrane protein biogenesis but not in response to the signal recognition particle-targeting defect or in response to a simple reduction in the abundance of the translocon. Together with the previous contention that the Cpx system senses a protein abnormality not only at periplasmic and outer membrane locations but also at the plasma membrane, abnormal states of membrane proteins are postulated to be generated in these secY mutants. In support of this notion, in vitro translation, membrane integration, and folding of LacY reveal that mutant membrane vesicles allow the insertion of LacY but not subsequent folding into a normal conformation recognizable by conformation-specific antibodies. The results demonstrate that normal SecY function is required for the folding of membrane proteins after their insertion into the translocon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.