ArticleClinical immunology (Orlando, Fla.)2007
Differential dysfunction in dendritic cell subsets during chronic HCV infection.
Article in Clinical immunology (Orlando, Fla.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 79 citations in OpenAlex.
- Hepatitis C in the Direct-Acting Antiviral Era: Immunopathogenesis, Dendritic Cells and Modern Clinical Management.Biomedicines · 2026Review
- Review
- Dendritic Cell Responses and Function in Malaria.Frontiers in immunology · 2019Review
- Mononuclear phagocyte system in hepatitis C virus infection.World journal of gastroenterology · 2018Review
- Reversing immune dysfunction and liver damage after direct-acting antiviral treatment for hepatitis C.Canadian liver journal · 2018Review
- IFN-α augments natural killer-mediated antibody-dependent cellular cytotoxicity of HIV-1-infected autologous CD4+ T cells regardless of major histocompatibility complex class 1 downregulation.AIDS (London, England) · 2017Article
- Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection.Journal of virology · 2016Article
- Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence.PLoS pathogens · 2016Article
- Role of A20 in interferon-α-mediated functional restoration of myeloid dendritic cells in patients with chronic hepatitis C.Immunology · 2014Article
- Dendritic cell maturation in HCV infection: altered regulation of MHC class I antigen processing-presenting machinery.Journal of hepatology · 2014Article
- CD81 and hepatitis C virus (HCV) infection.Viruses · 2014Review
- Influence of HIV and HCV on T cell antigen presentation and challenges in the development of vaccines.Frontiers in microbiology · 2014Review
- Success of antiviral therapy in chronic hepatitis C infection relates to functional status of myeloid dendritic cells.The Indian journal of medical research · 2013Review
- O death where is thy sting? Immunologic tolerance to apoptotic self.Cellular and molecular life sciences : CMLS · 2013Review
- Divergent contributions of regulatory T cells to the pathogenesis of chronic hepatitis C.Human vaccines & immunotherapeutics · 2013Review
- Sustained hyperresponsiveness of dendritic cells is associated with spontaneous resolution of acute hepatitis C.Journal of virology · 2013Article
- Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection.Hepatology (Baltimore, Md.) · 2012Article
- Review
- Review
- The type I interferon response during viral infections: a "SWOT" analysis.Reviews in medical virology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease with over 200 million individuals infected worldwide. The vast majority of acutely infected humans develop chronic infection, which is characterized by attenuated antiviral T-cell responses. The mechanisms leading to such attenuation/suppression are poorly understood. It has been proposed that dysfunction of antigen-presenting cells (APC) may underlie the downregulation of antiviral immune responses. However, studies using bulk or in vitro-derived APC populations have resulted in conflicting reports. In this study, we evaluated the functional and immunophenotypic features of ex vivo-purified dendritic cell (DC) subsets during chronic HCV infection. We found that plasmacytoid DC (PDC) from HCV-infected patients (HCV-PDC) showed a striking deficit in IFN-alpha production in response to CpG stimulation. In addition, we found that myeloid DC (MDC) from these patients showed a diminished capacity to induce a mixed lymphocyte response (MLR), correlating with lower levels of HLA-DR and CD86 expression and higher IL-10 production in response to poly-IC stimulation. In contrast, HCV-PDC showed increased ability to stimulate an MLR. Of note, within the HCV-PDC preparation, we noted a distinctly expanded DC subset that expressed some markers of MDC, but showed significantly lower HLA-DR and CD86 expression, suggesting an expansion of DC at an immature/intermediate stage of differentiation. Our studies demonstrate distinct and contrasting dysfunctional features in DC subsets and underscore the importance of evaluating APC subpopulations separately.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.