ArticleActa neuropathologica1991
Immunohistochemical characterization of primitive neuroectodermal tumors and their possible relationship to the stepwise ontogenetic development of the central nervous system. 1. Ontogenetic studies.
Article in Acta neuropathologica, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 50 citations in OpenAlex.
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- MYCN concurrence with SAHA-induced cell death in human neuroblastoma cells.Cellular oncology (Dordrecht, Netherlands) · 2015Article
- Granulocytic sarcoma in non-leukaemic child involving maxillary sinus with long term follow up: A rare case report.Annals of maxillofacial surgery · 2014Article
- Primitive neuroectodermal tumors of the central nervous system.Brain pathology (Zurich, Switzerland) · 1997Review
- Intra-axial endophytic primitive neuroectodermal tumors in the pons: clinical, radiological, and immunohistochemical aspects in four children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 1996Article
- Pineal parenchymal tumors: cell differentiation and prognosis.Journal of cancer research and clinical oncology · 1994Article
- Expression of phosphorylated high molecular weight neurofilament protein (NF-H) and vimentin in human developing dorsal root ganglia and spinal cord.Histochemistry · 1993Article
- Co-expression of low molecular weight neurofilament protein and glial fibrillary acidic protein in established human glioma cell lines.The American journal of pathology · 1993Article
- Immunohistochemical characterization of primitive neuroectodermal tumors and their possible relationship to the stepwise ontogenetic development of the central nervous system. 2. Tumor studies.Acta neuropathologica · 1991Article
- Multimodality treatment approach in management of primary peripheral primitive neuroectodermal tumor of the orbit.Indian journal of ophthalmologyArticle
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1 author at 1 institution in 1 country.
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Abstract
Aim of the present study was to establish different immunohistochemical staining patterns for a subsequent comparison with those of primitive neuroectodermal (PNET) subsets, i.e. PNET-NOS (not otherwise specified) or PNET with focal neuronal, astrocytic or ependymal differentiation, to relate neoplastic to embryonal development. Tissue of the developing central nervous system, with special emphasis on the stepwise development of the rhombencephalon, the cerebellar and the retinal anlage, from 20 different human embryos and fetuses ranging from 3 to 30 weeks of gestational age (GA) was examined. Six neuronal markers, synaptophysin, chromogranin A, neuron-specific enolase (NSE), neurofilament protein (NFP; 160 kDa, 200 kDa, 70 and 200 kDa) and six other markers, glial fibrillary acidic protein (GFAP), S-100 protein, vimentin, myoglobin, desmin, cytokeratin, were assessed immunohistochemically. GFAP and S-100 protein appeared at the 6th week of GA in primitive glial cells of the cerebellar anlage, brain stem, rhombencephalon, and developing spinal cord, together with--as first neuronal marker--chromogranin A, then NFP (70 and 200 kDa, and 160 kDa) from the 8th week onward. NSE started in the 11th week and synaptophysin not earlier than the 16th week of GA. Interestingly, the differentiation of the retinal anlage started rather late with NSE positivity beginning from the 16th week and positive reactions to synaptophysin and NFPs only from the 25th and chromogranin A from the 28th week of GA onward.
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