ReviewJournal of gastroenterology2007
Interaction between interleukin-17-producing CD4+ T cells and colonic subepithelial myofibroblasts: what are they doing in mucosal inflammation?
Review in Journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Association of single nucleotide polymorphisms of IL23R and IL17 with necrotizing enterocolitis in premature infants.Molecular and cellular biochemistry · 2017Trial
- Characterization of post-inflammatory irritable bowel syndrome animal model following acute colitis recovery.Scientific reports · 2025Article
- Bio-tensegrity and extracellular matrix disruption in the pathogenesis of persistent post-operative pain: a hypothesis.Frontiers in physiology · 2025Article
- Increased Vδ1γδT cells predominantly contributed to IL-17 production in the development of adult human post-infectious irritable bowel syndrome.BMC gastroenterology · 2021Article
- A Rare Case of New-Onset Ulcerative Colitis following Initiation of Secukinumab.Case reports in medicine · 2019Article
- Role of Interleukin- (IL-) 17 in the Pathogenesis and Targeted Therapies in Spondyloarthropathies.Mediators of inflammation · 2018Review
- What does irritable bowel syndrome share with non-alcoholic fatty liver disease?World journal of gastroenterology · 2013Review
- Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression.Journal of leukocyte biology · 2011Article
- Hematopoietic SCT modulates gut inflammation in experimental inflammatory bowel disease.Bone marrow transplantation · 2010Article
- Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome.World journal of gastrointestinal pathophysiology · 2010Article
- Inhibitory effects of short-chain fatty acids on matrix metalloproteinase secretion from human colonic subepithelial myofibroblasts.Digestive diseases and sciences · 2009Article
- Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease.Journal of gastroenterology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have shown alterations and activations in the mucosal immune system in patients with irritable bowel syndrome (IBS) as well as in those with inflammatory bowel disease (IBD). As one of effectors of mucosal inflammation, a new lineage of effector CD4+ T cells characterized by production of interleukin (IL)-17, the T-helper (Th)-17 lineage, was recently described. Th-17 cells are developmentally and functionally distinct from Th1 and Th2 cells. Here, we discuss the recent concept of low-grade inflammation as a factor associated with the pathophysiology of IBS. Furthermore, based on the data from our laboratory, interaction between Th-17 cells and colonic subepithelial myofibroblasts may play an important role in the pathophysiology of IBS and IBD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.