ReviewStem cell reviews2006
Normal breast stem cells, malignant breast stem cells, and the perinatal origin of breast cancer.
Review in Stem cell reviews, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review.Breast cancer research : BCR · 2016Pooled it
- Lifecourse Growth and Development Determinants of Mammographic Density in Black Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Associations of Early-Life and Adult Anthropometric Measures with the Expression of Stem Cell Markers CD44, CD24, and ALDH1A1 in Women with Benign Breast Biopsies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Recent Advances in Targeting of Breast Cancer Stem Cells Based on Biological Concepts and Drug Delivery System Modification.Advanced pharmaceutical bulletin · 2020Review
- Associations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes.Cancer causes & control : CCC · 2019Article
- Tissue-based associations of mammographic breast density with breast stem cell markers.Breast cancer research : BCR · 2017Article
- Reproductive factors related to childbearing and mammographic breast density.Breast cancer research and treatment · 2016Article
- Effect of preeclampsia on umbilical cord blood stem cells in relation to breast cancer susceptibility in the offspring.Carcinogenesis · 2015Article
- Screening preeclamptic cord plasma for proteins associated with decreased breast cancer susceptibility.Genomics, proteomics & bioinformatics · 2013Article
- Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway.Cell cycle (Georgetown, Tex.) · 2013Article
- Novel measurements of mammary stem cells in human umbilical cord blood as prospective predictors of breast cancer susceptibility in later life.Annals of oncology : official journal of the European Society for Medical Oncology · 2012Article
- Prenatal modulation of breast density and breast stem cells by insulin-like growth factor-1.American journal of stem cells · 2012Article
- Birth weight and other prenatal factors and risk of breast cancer in Asian-Americans.Breast cancer research and treatment · 2011Article
- Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2008Review
- Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis.Breast cancer research : BCR · 2007Article
- Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Both experimental and epidemiological evidence support the concept that the in utero environment can influence an individual's risk of breast cancer in adult life. Recently identified breast stem cells may be the key to understanding the mechanism underlying this phenomenon. It has been theorized that breast cancers arise from breast stem cells. Our emerging view of the characteristics of normal breast stem cells and their link to malignant breast stem cells is reviewed here. It has also been postulated that factors that expand the normal breast stem cell pool in utero would increase the probability that one such cell might undergo an oncogenic mutation or epigenetic change. We discuss how a number of proposed perinatal determinants of adult breast cancer risk, including (1) in utero estrogen and IGF-1 levels, (2) birthweight, (3) breast density, and (4) early-life mutagen exposure, can be tied together by this "breast stem cell burden" hypothesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.