ArticleGenetics2007
Glucose-responsive regulators of gene expression in Saccharomyces cerevisiae function at the nuclear periphery via a reverse recruitment mechanism.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Nuclear basket proteins Nup2 and Mlp1 drive heat shock-induced 3D genome restructuring downstream of transcriptional activation.The Journal of biological chemistry · 2025Article
- Nuclear basket proteins Nup2 and Mlp1 drive heat shock-induced 3D genome restructuring downstream of transcriptional activation.bioRxiv : the preprint server for biology · 2025Article
- Subnuclear gene positioning through lamina association affects copper tolerance.Nature communications · 2020Article
- Regulating Strategies for Producing Carbohydrate Active Enzymes by Filamentous Fungal Cell Factories.Frontiers in bioengineering and biotechnology · 2020Review
- The Role of Transcription Factors and Nuclear Pore Proteins in Controlling the Spatial Organization of the Yeast Genome.Developmental cell · 2019Article
- Nuclear pore complexes and regulation of gene expression.Current opinion in cell biology · 2017Review
- Sumoylation and transcription regulation at nuclear pores.Chromosoma · 2015Review
- Nuclear pore proteins and the control of genome functions.Genes & development · 2015Review
- From hypothesis to mechanism: uncovering nuclear pore complex links to gene expression.Molecular and cellular biology · 2014Review
- Nuclear pore interactions with the genome.Current opinion in genetics & development · 2014Review
- Light-regulated gene repositioning in Arabidopsis.Nature communications · 2014Article
- Article
- Snf1/AMPK regulates Gcn5 occupancy, H3 acetylation and chromatin remodelling at S. cerevisiae ADY2 promoter.Biochimica et biophysica acta · 2012Article
- A negative feedback loop at the nuclear periphery regulates GAL gene expression.Molecular biology of the cell · 2012Article
- The yeast nuclear pore complex and transport through it.Genetics · 2012Article
- Review
- Toward a global analysis of metabolites in regulatory mutants of yeast.Analytical and bioanalytical chemistry · 2011Article
- Gene positioning and expression.Current opinion in cell biology · 2011Review
- Nuclear organization: taking a position on gene expression.Current opinion in cell biology · 2011Review
- Application of structure equation modeling for inferring a serial transcriptional regulation in yeast.Gene regulation and systems biology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Regulation of gene transcription is a key feature of developmental, homeostatic, and oncogenic processes. The reverse recruitment model of transcriptional control postulates that eukaryotic genes become active by moving to contact transcription factories at nuclear substructures; our previous work showed that at least some of these factories are tethered to nuclear pores. We demonstrate here that the nuclear periphery is the site of key events in the regulation of glucose-repressed genes, which together compose one-sixth of the Saccharomyces cerevisiae genome. We also show that the canonical glucose-repressed gene SUC2 associates tightly with the nuclear periphery when transcriptionally active but is highly mobile when repressed. Strikingly, SUC2 is both derepressed and confined to the nuclear rim in mutant cells where the Mig1 repressor is nuclear but not perinuclear. Upon derepression all three subunits (alpha, beta, and gamma) of the positively acting Snf1 kinase complex localize to the nuclear periphery, resulting in phosphorylation of Mig1 and its export to the cytoplasm. Reverse recruitment therefore appears to explain a fundamental pathway of eukaryotic gene regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.