ArticleGenetics2007
The role of pleiotropy in the maintenance of sex in yeast.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load.Science (New York, N.Y.) · 2026Article
- Pleiotropy and the evolutionary stability of plastic phenotypes: a geometric framework.G3 (Bethesda, Md.) · 2026Article
- Effect of Salt Stress on Mutation and Genetic Architecture for Fitness Components inG3 (Bethesda, Md.) · 2020Article
- Spontaneous whole-genome duplication restores fertility in interspecific hybrids.Nature communications · 2019Article
- Genetically integrated traits and rugged adaptive landscapes in digital organisms.BMC evolutionary biology · 2015Article
- Pleiotropy of the de novo-originated gene MDF1.Scientific reports · 2014Article
- Asexual reproduction induces a rapid and permanent loss of sexual reproduction capacity in the rice fungal pathogen Magnaporthe oryzae: results of in vitro experimental evolution assays.BMC evolutionary biology · 2012Article
- Mutator dynamics in sexual and asexual experimental populations of yeast.BMC evolutionary biology · 2011Article
- Genomic patterns of pleiotropy and the evolution of complexity.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution.Biology direct · 2010Article
- Evolution of mutational robustness in the yeast genome: a link to essential genes and meiotic recombination hotspots.PLoS genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In facultatively sexual species, lineages that reproduce asexually for a period of time can accumulate mutations that reduce their ability to undergo sexual reproduction when sex is favorable. We propagated Saccharomyces cerevisiae asexually for approximately 800 generations, after which we measured the change in sexual fitness, measured as the proportion of asci observed in sporulation medium. The sporulation rate in cultures propagated asexually at small population size declined by 8%, on average, over this time period, indicating that the majority of mutations that affect sporulation rate are deleterious. Interestingly, the sporulation rate in cultures propagated asexually at large population size improved by 11%, on average, indicating that selection on asexual function effectively eliminated most of the mutations deleterious to sporulation ability. These results suggest that pleiotropy between mutations' effects on asexual fitness and sexual fitness was predominantly positive, at least for the mutations accumulated in this experimental evolution study. A positive correlation between growth rate and sporulation rate among lines also provided evidence for positive pleiotropy. These results demonstrate that, at least under certain circumstances, selection acting on asexual fitness can help to maintain sexual function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.