ArticleJournal of immunology (Baltimore, Md. : 1950)2007
Expression and function of synaptotagmin VII in CTLs.
Article in Journal of immunology (Baltimore, Md. : 1950), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Lytic granule exocytosis at immune synapses: lessons from neuronal synapses.Frontiers in immunology · 2023Review
- Molecular regulation of the plasma membrane-proximal cellular steps involved in NK cell cytolytic function.Journal of cell science · 2020Review
- Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes.Frontiers in immunology · 2020Article
- A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity.The Journal of physiology · 2018Article
- The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis.The Journal of general physiology · 2018Review
- The multifaceted role of PIP2 in leukocyte biology.Cellular and molecular life sciences : CMLS · 2015Review
- Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes.Immunology · 2015Article
- Activation of Lymphocyte Cytolytic Machinery: Where are We?Frontiers in immunology · 2013Review
- Multiple roles for the actin cytoskeleton during regulated exocytosis.Cellular and molecular life sciences : CMLS · 2013Review
- Stimulation of MMP-1 and CCL2 by NAMPT in PDL cells.Mediators of inflammation · 2013Article
- Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion.The Journal of cell biology · 2012Article
- ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells.Cell communication and signaling : CCS · 2011Article
- Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.Nature reviews. Immunology · 2010Review
- Leukocyte chemotaxis: from lysosomes to motility.Nature immunology · 2010Article
- P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways.Purinergic signalling · 2009Article
- Two-way traffic on the road to plasma membrane repair.Trends in cell biology · 2008Review
- Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion.Developmental cell · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Ca(2+) sensor synaptotagmin (Syt) VII regulates the exocytosis of conventional lysosomes in several cell types. In CTLs, the Ca(2+)-regulated exocytosis of lytic granules/secretory lysosomes is responsible for the perforin/granzyme-mediated lysis of target cells. To investigate the role of Syt VII in CTL effector function, the expression and function of Syt VII were examined in wild-type and Syt VII-deficient mice. In comparison with Syt VII(+/+) controls, Syt VII(-/-) animals were impaired in their ability to clear an infection with the intracellular pathogen Listeria monocytogenes. When isolated CTLs were examined, we found that Syt VII is expressed upon CTL activation and localizes to granzyme A-containing lytic granules. Syt VII-deficient CTLs have no defects in proliferation and cytokine production, and their lytic granules contain normal amounts of perforin and granzyme A and polarize normally at the immunological synapse. However, despite normal conjugate formation with target cells, CTLs from Syt VII(-/-) mice exhibit reduced effector activity, when compared with controls. Treatment of Syt VII(+/+) or Syt VII(-/-) CTLs with an inhibitor of the perforin-mediated lytic pathway resulted in comparable levels of cytotoxic activity, suggesting that Syt VII regulates perforin-mediated cytolytic CTL responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.