Evidence map›Paper›PMID 17237299›Full record

SynthesisBMJ (Clinical research ed.)2007

Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis.

Clare L Gillies, Keith R Abrams, Paul C Lambert, Nicola J Cooper, Alex J Sutton, Ron T Hsu, Kamlesh Khunti

2 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 438 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
438citing papers in PubMed, 21 pooled it
53.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05609266 completednot on this map

Validation of Non-invasive Risk Models for Prediction of Incident Type 2 Diabetes in a Swedish Population

TypeobservationalSponsorUmeå UniversityRan1990 to 2020Enrolled115,642ConditionsType2diabetes
NCT05837468 unknown statusnot on this mapstarted 2023, after this paper: background citation

Better App: (Further-)Development and Evaluation of a Digital Lifestyle Programme Based on Subtypes for Overweight or Obese People

TypeobservationalSponsorZuyd University of Applied SciencesRan2023 to 2023Enrolled65ConditionsHealthy Lifestyle, Health BehaviorArmsBETTERapp
3 · Its place in the literature

Who cites it

438 citing papers in PubMed, 21 syntheses or guidelines pooled it, 1,191 citations in OpenAlex.

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  9. Gamification for Family Engagement in Lifestyle Interventions: A Systematic Review.Prevention science : the official journal of the Society for Prevention Research · 2021
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378 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Clare L GilliesCentre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester LE1 7RH. clg13@le.ac.uk
Keith R Abrams
Paul C Lambert
Nicola J Cooper
Alex J Sutton
Ron T Hsu
Kamlesh Khunti
University of Leicester · GB

Funding

Medical Research Council G106/1170
6 · The paper itself

Abstract

objectiveTo quantify the effectiveness of pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance. DATA SOURCES: Medline, Embase, and the Cochrane library searched up to July 2006. Expert opinions sought and reference lists of identified studies and any relevant published reviews checked. STUDY SELECTION: Randomised controlled trials that evaluated interventions to delay or prevent type 2 diabetes in individuals with impaired glucose tolerance.

results21 trials met the inclusion criteria, of which 17, with 8084 participants with impaired glucose tolerance, reported results in enough detail for inclusion in the meta-analyses. From the meta-analyses the pooled hazard ratios were 0.51 (95% confidence interval 0.44 to 0.60) for lifestyle interventions v standard advice, 0.70 (0.62 to 0.79) for oral diabetes drugs v control, 0.44 (0.28 to 0.69) for orlistat v control, and 0.32 (0.03 to 3.07) for the herbal remedy jiangtang bushen recipe v standard diabetes advice. These correspond to numbers needed to treat for benefit (NNTB) and harm (NNTH) of 6.4 for lifestyle (95% credible interval, NNTB 5.0 to NNTB 8.4), 10.8 for oral diabetes drugs (NNTB 8.1 to NNTB 15.0), 5.4 for orlistat (NNTB 4.1 to NNTB 7.6), and 4.0 for jiangtang bushen (NNTH 16.9 to NNTB 24.8).

conclusionsLifestyle and pharmacological interventions reduce the rate of progression to type 2 diabetes in people with impaired glucose tolerance. Lifestyle interventions seem to be at least as effective as drug treatment.

Indexed as

Life StyleDiabetes Mellitus, Type 2Glucose IntoleranceHumansHypoglycemic AgentsPublication BiasRandomized Controlled Trials as TopicTreatment OutcomeHypoglycemic Agents

Identifiers

PMID17237299
PMCPMC1796695
OpenAlexW2096691922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.