ArticleProceedings of the National Academy of Sciences of the United States of America2007
Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait loci.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 2 of them syntheses that pooled it.
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Who cites it
163 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches.PLoS genetics · 2013Pooled it
- Gene regulatory network reconstruction using Bayesian networks, the Dantzig Selector, the Lasso and their meta-analysis.PloS one · 2011Pooled it
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- Integrative transcriptogenomic analyses reveal the regulatory network underlying rice eating and cooking quality and identify a role for alpha-globulin in modulating starch and sucrose metabolism.Plant communications · 2025Article
- eQTL mapping in transgenic alpha-synuclein carrying Caenorhabditis elegans recombinant inbred lines.Human molecular genetics · 2024Article
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- A systems genomics and genetics approach to identify the genetic regulatory network for lignin content inFrontiers in plant science · 2024Article
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- Plasticity of maternal environment-dependent expression-QTLs of tomato seeds.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- A Network-Based Approach for Improving Annotation of Transcription Factor Functions and Binding Sites inGenes · 2023Article
- Molecular mechanisms underpinning quantitative resistance toFrontiers in plant science · 2023Article
- Multi-omics analysis reveals the genetic basis of rice fragrance mediated by betaine aldehyde dehydrogenase 2.Journal of advanced research · 2022Article
- Network reconstruction for trans acting genetic loci using multi-omics data and prior information.Genome medicine · 2022Article
- Prioritizing candidate eQTL causal genes in Arabidopsis using RANDOM FORESTS.G3 (Bethesda, Md.) · 2022Article
- Evolutionary systems biology reveals patterns of rice adaptation to drought-prone agro-ecosystems.The Plant cell · 2022Article
- Article
- Inheritance of gene expression throughout fruit development in chili pepper.Scientific reports · 2021Article
- A systems genetics approach reveals PbrNSC as a regulator of lignin and cellulose biosynthesis in stone cells of pear fruit.Genome biology · 2021Article
103 more citing papers are in PubMed but not listed here.
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Accessions of a plant species can show considerable genetic differences that are analyzed effectively by using recombinant inbred line (RIL) populations. Here we describe the results of genome-wide expression variation analysis in an RIL population of Arabidopsis thaliana. For many genes, variation in expression could be explained by expression quantitative trait loci (eQTLs). The nature and consequences of this variation are discussed based on additional genetic parameters, such as heritability and transgression and by examining the genomic position of eQTLs versus gene position, polymorphism frequency, and gene ontology. Furthermore, we developed an approach for genetic regulatory network construction by combining eQTL mapping and regulator candidate gene selection. The power of our method was shown in a case study of genes associated with flowering time, a well studied regulatory network in Arabidopsis. Results that revealed clusters of coregulated genes and their most likely regulators were in agreement with published data, and unknown relationships could be predicted.
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