ArticleJournal of neurology, neurosurgery, and psychiatry2007
A prospective study of secondary degeneration following subcortical infarction using diffusion tensor imaging.
Article in Journal of neurology, neurosurgery, and psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 110 citations in OpenAlex.
- Neuroplastic Mechanisms of Acupuncture in Post-Stroke Motor Recovery: A Randomized Multimodal MRI Trial.CNS neuroscience & therapeutics · 2026Trial
- Analysis of correlation between structural changes and functional response in post-stroke motor recovery after cM1 LF-rTMS: an exploratory randomized trial.Scientific reports · 2026Trial
- Cortical atrophy and transcallosal diaschisis following isolated subcortical stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Structural plasticity of remote cortical brain regions is determined by connectivity to the primary lesion in subcortical stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Trial
- Validation of network communicability metrics for the analysis of brain structural networks.PloS one · 2014Trial
- Wallerian degeneration in the corticospinal tract evaluated by diffusion tensor imaging correlates with motor deficit 30 days after middle cerebral artery ischemic stroke.AJNR. American journal of neuroradiology · 2010Trial
- Tract-specific and region of interest analysis of corticospinal tract integrity in subcortical ischemic stroke: reliability and correlation with motor function of affected lower extremity.AJNR. American journal of neuroradiology · 2010Trial
- Histopathological Changes of the Corticospinal Tract Following Hemorrhagic and Ischemic Stroke.Brain sciences · 2025Article
- Clinical Relevance of 'Cap' and 'Track' Development after Recent Small Subcortical Infarct.Annals of neurology · 2025Article
- Association Between Changes in White Matter Volume Detected With Diffusion Tensor-Based Morphometry and Motor Recovery After Stroke.Neurology · 2025Article
- PARP9 exacerbates apoptosis and neuroinflammation via the PI3K pathway in the thalamus and hippocampus and cognitive decline after cortical infarction.Journal of neuroinflammation · 2025Article
- Microstructure of the residual corticofugal projection from primary motor cortex in chronic stroke.Brain communications · 2025Article
- Stroke-Induced Secondary Neurodegeneration of the Corticospinal Tract-Time Course and Mechanisms Underlying Signal Changes in Conventional and Advanced Magnetic Resonance Imaging.Journal of clinical medicine · 2024Review
- Association between preoperative white matter hyperintensities and postoperative new ischemic lesions on magnetic resonance imaging in patients with cognitive decline after carotid endarterectomy.Neurosurgical review · 2024Observational
- Differential Responses of Retinal Neurons and Glia Revealed via Proteomic Analysis on Primary and Secondary Retinal Ganglion Cell Degeneration.International journal of molecular sciences · 2023Article
- Investigating secondary white matter degeneration following ischemic stroke by modelling affected fiber tracts.NeuroImage. Clinical · 2022Article
- A pilot [Brain, behavior, & immunity - health · 2021Article
- Longitudinal changes in the inferior cerebellar peduncle and lower limb motor recovery following subcortical infarction.BMC neurology · 2021Article
- Article
- Investigating the Association of Wallerian Degeneration and Diaschisis After Ischemic Stroke With BOLD Cerebrovascular Reactivity.Frontiers in physiology · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSecondary degeneration of the pyramidal tract distal to the primary lesion after a stroke has been detected by some studies using diffusion tensor imaging (DTI) but its potential clinical significance and the degeneration of the fibre tract proximal to the primary lesion have received little attention.
methodsTwelve patients underwent DTI on the 1st, 4th and 12th week following a subcortical infarct involving the posterior limb of the internal capsule, and 12 age and sex matched controls underwent DTI once. The DTI parameters mean diffusivity and fractional anisotropy (FA), and the clinical scores before DTI examination, including the National Institutes of Health Stroke Scale (NIHSS), the Fugl-Meyer (FM) scale and the Barthel index (BI), were assessed. The relations between the per cent changes in DTI parameters and clinical scores were analysed.
resultsFrom the 1st to the 12th week after stroke onset, FA values decreased (p<0.01, respectively) in the fibre tract above and below the internal capsule, and the NIHSS decreased (p<0.01) but the FM scale and BI increased (p<0.01, respectively) progressively. The per cent reductions in FA value in the fibre tract above and below the internal capsule were negatively correlated with the per cent changes in NIHSS and FM scale (p<0.05, respectively).
conclusionsSecondary degeneration of the fibre tract proximal and distal to a primary lesion can be detected by DTI clearly and quantitatively and deteriorates with time progressively, which may hamper functional recovery after a subcortical cerebral infarct.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.