ArticleAmerican journal of surgery2007
Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate.
Article in American journal of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 77 citations in OpenAlex.
- A GMP-compliant formulation of regeneratively active polyphosphate for wound healing and skin regeneration.Biomaterials science · 2026Article
- Engineered ATP-loaded extracellular vesicles: a dual-functional strategy for improving myocardial infarction therapy.Drug delivery and translational research · 2026Article
- Therapeutic potential of human mesenchymal stromal cell-derived mitochondria in a rat model of surgical digestive fistula.Scientific reports · 2025Article
- Engineered ATP-Loaded Extracellular Vesicles Derived from Mesenchymal Stromal Cells: A Novel Strategy to Counteract Cell ATP Depletion in an In Vitro Model.International journal of molecular sciences · 2025Article
- Antioxidant Effect of a Plant-Derived Extracellular Vesicles' Mix on Human Skin Fibroblasts: Induction of a Reparative Process.Antioxidants (Basel, Switzerland) · 2024Article
- The Use of Extracellular Vesicles in Achilles Tendon Repair: A Systematic Review.Biomedicines · 2024Review
- The Physiological Inorganic Polymers Biosilica and Polyphosphate as Key Drivers for Biomedical Materials in Regenerative Nanomedicine.International journal of nanomedicine · 2024Review
- Roles of extracellular adenosine triphosphate on the functions of periodontal ligament cells.BDJ open · 2023Review
- ENERGI-F703 gel, as a new topical treatment for diabetic foot and leg ulcers: A multicenter, randomized, double-blind, phase II trial.EClinicalMedicine · 2022Article
- Efficacy of topical Miltefosine formulations in an experimental model of cutaneous leishmaniasis.Drug delivery and translational research · 2022Article
- Optimal Fluence and Duration of Low-Level Laser Therapy for Efficient Wound Healing in Mice.Annals of dermatology · 2021Article
- Photobiomodulation by Near-Infrared 980-nm Wavelengths Regulates Pre-Osteoblast Proliferation and Viability through the PI3K/Akt/Bcl-2 Pathway.International journal of molecular sciences · 2021Article
- Enhanced Skin Incisional Wound Healing With Intracellular ATP DeliveryFrontiers in pharmacology · 2021Article
- Extracellular release of ATP promotes systemic inflammation during acute pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Therapeutic strategies for enhancing angiogenesis in wound healing.Advanced drug delivery reviews · 2019Review
- Intracellular ATP Delivery Causes Rapid Tissue RegenerationFrontiers in pharmacology · 2019Article
- Development of a novel in situ gelling skin dressing: Delivering high levels of dissolved oxygen at pH 5.5.Health science reports · 2018Article
- Macrophage Differentiation in Normal and Accelerated Wound Healing.Results and problems in cell differentiation · 2017Review
- Rapid tissue regeneration induced by intracellular ATP delivery-A preliminary mechanistic study.PloS one · 2017Article
- Spatiotemporal phosphoprotein distribution and associated cytokine response of a traumatic injury.Cytokine · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA new intracellular adenosine triphosphate (ATP) delivery technique has been developed and was tested for skin wound care.
methodsEleven pairs of adult nude mice were used. ATP-vesicles were applied in 11 mice, and another 11 mice were treated with lipid vesicles only.
resultsThe group treated with ATP-encapsulated fusogenic small, unilamellar lipid vesicles healed faster than the group treated with only lipid vesicles. Histologic study indicated better developed granular tissue and re-epithelialization in the study group, and wound tissue vascular endothelial growth factor expressions were also higher in ATP-vesicles treated mice.
conclusionsThis intracellular ATP delivery system may provide a new hope for wound healing as well as the treatment of medical conditions in which ischemia is involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.