Trial reportThe Journal of steroid biochemistry and molecular biology2007
Falls are associated with decreased renal function and insufficient calcitriol production by the kidney.
Trial report in The Journal of steroid biochemistry and molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Interventions for preventing falls in older people living in the community.The Cochrane database of systematic reviews · 2012Pooled it
- Association of 1,25-dihydroxyvitamin D levels with physical performance and thigh muscle cross-sectional area in chronic kidney disease stage 3 and 4.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2012Trial
- Association between glomerular filtration rate and comprehensive geriatric assessment parameters in older adults.International urology and nephrology · 2026Article
- Accidental falling in community-dwelling elderly with chronic kidney disease.International urology and nephrology · 2019Article
- Factors associated with falls in older adults with cancer: a validated model from the Cancer and Aging Research Group.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- The effect of hemodialysis on balance measurements and risk of fall.International urology and nephrology · 2016Article
- [Decline in renal function in old age : Part of physiological aging versus age-related disease].Zeitschrift fur Gerontologie und Geriatrie · 2016Article
- 1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells.The Journal of biological chemistry · 2016Article
- Chronic Kidney Disease-Mineral Bone Disorder in the Elderly Peritoneal Dialysis Patient.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2015Review
- Vitamin D and neurocognitive function.Clinical interventions in aging · 2014Review
- Vitamin D and aging.Endocrinology and metabolism clinics of North America · 2013Review
- Fracture risk assessment in patients with chronic kidney disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Review
- Cardiorespiratory fitness is independently associated with 25-hydroxyvitamin D in chronic kidney disease.Clinical journal of the American Society of Nephrology : CJASN · 2011Article
- Independent and combined effects of exercise and vitamin D on muscle morphology, function and falls in the elderly.Nutrients · 2010Review
- Renal senescence in 2008: progress and challenges.International urology and nephrology · 2008Review
- Chronic kidney disease and recurrent falls in nursing home residents: a retrospective cohort study.Geriatric nursing (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In a double blind placebo controlled 3-year osteoporosis study in elderly women, we collected prospective data on falls. The study population comprised 489 normal elderly women aged 65-77 years randomized to four groups: placebo, calcitriol 0.25 mcg b.i.d., conjugated equine estrogens (0.625 mg/day) and calcitriol+estrogen. Falls occurred in 57% of all women. Using a Poisson regression model, the placebo group with low GFR-creatinine clearance (CrCl<60 ml/min) had 60% more falls compared to the group with CrCl> or =60 ml/min. Further sub group analyses showed that there is no increased risk of falls with CrCl 60-70, 70-80 and >90 ml/min. Calcitriol treatment significantly reduced the number of falls by 50% (OR=0.5, 95% CI: 0.4-0.9, p=0.010) compared to placebo in the low CrCl group. The group with lower CrCl had lower calcium absorption (p<0.001), lower serum 1,25-dihydroxyvitamin D (1,25(OH)(2)D) (p<0.001) and normal serum 25OHD suggesting that there is decreased conversion of 25OHD to 1,25(OH)(2)D by the aging kidney. It is postulated that the decrease in falls on calcitriol therapy is related to an increase in serum 1,25(OH)(2)D, upregulation of VDR and improvement in muscle strength although one cannot exclude an effect on the central nervous system.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.