ArticleAmerican journal of human genetics2007
Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00069589 (Alopecia Areata Registry and Immunogenetic Mechanisms), which is not on this map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Alopecia Areata Registry and Immunogenetic Mechanisms
Who cites it
50 citing papers in PubMed, 149 citations in OpenAlex.
- Therapeutic update on alopecia areata: a critical review of standard and emerging targeted therapies.Inflammopharmacology · 2026Review
- Case Reports of Alopecia Areata Associated With Apical Periodontitis.Case reports in dentistry · 2026Article
- Epidermal γδ T cells, CD8 T cells and macrophages are increased in number in alopecia areata and express BST2 as part of an interferon-driven antiviral gene signature.bioRxiv : the preprint server for biology · 2025Article
- Case Report: A novel KRT74 variant in an eight-year-old boy with alopecia totalis successfully treated with baricitinib.Frontiers in medicine · 2025Article
- Case Series and Literature Review on Tofacitinib for Treating Severe Alopecia Areata.Clinical, cosmetic and investigational dermatology · 2025Article
- Recent advances in the genetics of alopecia areata.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2023Article
- Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles.Clinical, cosmetic and investigational dermatology · 2023Article
- Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82.Nature communications · 2022Article
- Immunopathology and Immunotherapy of Inflammatory Skin Diseases.Immune network · 2022Review
- The Immunogenetics of Alopecia areata.Advances in experimental medicine and biology · 2022Article
- Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management.Clinical reviews in allergy & immunology · 2021Review
- Cognitive Process of Psoriasis and Its Comorbidities: From Epidemiology to Genetics.Frontiers in genetics · 2021Review
- A Hairy Cituation - PADIs in Regeneration and Alopecia.Frontiers in cell and developmental biology · 2021Review
- An Imperative Need for Further Genetic Studies of Alopecia Areata.The journal of investigative dermatology. Symposium proceedings · 2020Review
- Macrophage Migration Inhibitory Factor in Alopecia Areata and Vitiligo: A Case-Controlled Serological Study.The Journal of clinical and aesthetic dermatology · 2020Article
- Integrative analysis of rare copy number variants and gene expression data in alopecia areata implicates an aetiological role for autophagy.Experimental dermatology · 2020Article
- Immunology of alopecia areata.Central-European journal of immunology · 2020Review
- Clinico-dermoscopic features of alopecia areata in patients with psoriasis.JAAD case reports · 2018Article
- Topical Immunotherapy of Alopecia Areata: A Large Retrospective Study.Dermatology and therapy · 2018Article
- Alopecia Areata: a Comprehensive Review of Pathogenesis and Management.Clinical reviews in allergy & immunology · 2018Review
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 2 countries.
Funding
Abstract
Alopecia areata (AA) is a genetically determined, immune-mediated disorder of the hair follicle that affects 1%-2% of the U.S. population. It is defined by a spectrum of severity that ranges from patchy localized hair loss on the scalp to the complete absence of hair everywhere on the body. In an effort to define the genetic basis of AA, we performed a genomewide search for linkage in 20 families with AA consisting of 102 affected and 118 unaffected individuals from the United States and Israel. Our analysis revealed evidence of at least four susceptibility loci on chromosomes 6, 10, 16 and 18, by use of several different statistical approaches. Fine-mapping analysis with additional families yielded a maximum multipoint LOD score of 3.93 on chromosome 18, a two-point affected sib pair (ASP) LOD score of 3.11 on chromosome 16, several ASP LOD scores >2.00 on chromosome 6q, and a haplotype-based relative risk LOD of 2.00 on chromosome 6p (in the major histocompatibility complex locus). Our findings confirm previous studies of association of the human leukocyte antigen locus with human AA, as well as the C3H-HeJ mouse model for AA. Interestingly, the major loci on chromosomes 16 and 18 coincide with loci for psoriasis reported elsewhere. These results suggest that these regions may harbor gene(s) involved in a number of different skin and hair disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.