ArticleVirchows Archiv : an international journal of pathology2007
Expression of transcription factors and precursor cell markers during regeneration of beta cells in pancreata of rats treated with streptozotocin.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes.Diabetologia · 2017Article
- A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase.Diabetologia · 2015Review
- Genetic variants of the HSD11B1 gene promoter may be protective against polycystic ovary syndrome.Molecular biology reports · 2014Article
- Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse model.Diabetologia · 2012Article
- Inhibition of Gsk3β activity improves β-cell function in c-KitWv/+ male mice.Laboratory investigation; a journal of technical methods and pathology · 2012Article
- Erythropoietin protects against diabetes through direct effects on pancreatic beta cells.The Journal of experimental medicine · 2010Article
- Attacking the source: anti-PDX-1 responses in type 1 diabetes.Laboratory investigation; a journal of technical methods and pathology · 2010Article
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3 authors at 1 institution in 1 country.
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Abstract
An understanding of beta cell regeneration is needed if we are to develop new treatment modalities in diabetes mellitus. Lineage tracing studies have shown that all pancreatic cell types, including beta cells, arise from PDX-1-expressing precursor cells. We studied beta cell regeneration by analyzing the immunocytochemical expression of the transcription factors, PDX-1, PBX-1, and MEIS2, and that of the potential precursor cell markers, c-Kit and nestin, using the model of streptozotocin (STZ)-induced diabetes in rats. The pancreata were examined 3, 7, and 14 days after STZ administration. PDX-1 expression, but not that of MEIS2 and PBX-1, transiently increased on day 7. c-Kit expression was found to be upregulated in islet cells at all points in time, while nestin expression was lacking. Ki-67 labeling was increased in islets on days 3 and 7. These results suggest that temporary upregulation of PDX-1 and prolonged overexpression of c-Kit may play a role during beta cell regeneration.
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