ArticleIntensive care medicine2007
Infectious complications of percutaneous central venous catheterization in pediatric patients: a Spanish multicenter study.
Article in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Skin antisepsis for reducing central venous catheter-related infections.The Cochrane database of systematic reviews · 2016Pooled it
- Antimicrobial dressings for the prevention of catheter-related infections in newborn infants with central venous catheters.The Cochrane database of systematic reviews · 2016Pooled it
- Central Venous Catheter-Related Infectious Complications in Pediatric Surgical Patients: A Single-Center Experience.Journal of pediatric intensive care · 2022Article
- The effects of TGF-β1 on staphylococcus epidermidis biofilm formation in a tree shrew biomaterial-centered infection model.Annals of translational medicine · 2021Article
- Fatal neonatal persistent pulmonary hypertension caused by vegetations of infective endocarditis - case report and review of the literature.Archive of clinical cases · 2020Article
- Article
- Adult 'PICC' Device May be Used as a Tunnelled Central Venous Catheter in Children.Cardiovascular and interventional radiology · 2018Article
- Prevention of transmission of multidrug-resistant organisms during catheter exchange using antimicrobial catheters.Antimicrobial agents and chemotherapy · 2014Article
- Catheter dwell time and CLABSIs in neonates with PICCs: a multicenter cohort study.Pediatrics · 2013Article
- Bench-to-bedside review: Challenges of diagnosis, care and prevention of central catheter-related bloodstream infections in children.Critical care (London, England) · 2013Review
- Healthcare-associated infection prevention in pediatric intensive care units: a review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Review
- Central line-associated bloodstream infection in hospitalized children with peripherally inserted central venous catheters: extending risk analyses outside the intensive care unit.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Article
- Intervention to reduce catheter-related bloodstream infections in a pediatric intensive care unit.Intensive care medicine · 2011Article
- Catheter duration and risk of CLA-BSI in neonates with PICCs.Pediatrics · 2010Article
- Mechanical complications during central venous cannulations in pediatric patients.Intensive care medicine · 2009Article
- Do routine catheter-tip cultures in the paediatric intensive care unit impact management?Intensive care medicine · 2009Article
- Risk factors and prognosis of catheter-related bloodstream infection in critically ill patients: a multicenter study.Intensive care medicine · 2008Article
- Central venous catheters in children and neonates (Part 3) - Access via the femoral vein.Images in paediatric cardiology · 2008Article
- Year in review in Intensive Care Medicine, 2007. III. Ethics and legislation, health services research, pharmacology and toxicology, nutrition and paediatrics.Intensive care medicine · 2008Review
- Central venous catheters in children and neonates (Part 2) - Access via the internal jugular vein.Images in paediatric cardiology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAnalysis of infectious complications and risk factors in percutaneous central venous catheters.
designOne-year observational, prospective, multicenter study (1998-1999).
settingTwenty Spanish pediatric intensive care units. PATIENTS: Eight hundred thirty-two children aged 0-14 years.
interventionNone. MEASUREMENTS AND MAIN
resultsOne thousand ninety-two catheters were analyzed. Seventy-four (6.81%) catheter-related bloodstream infections (CRBSI) were found. The CRBSI rate was 6.4 per 1,000 CVC days (95% CI 5.0-8.0). Risk factors for CRBSI were weight under 8 kg (p < 0.001), cardiac failure (RR 2.69; 95% CI 1.95-4.38; p < 0.001), cancer (RR 1.66; 95% CI 0.97-2.78; p=0.05), silicone catheters (RR 2.82; 95% CI 1.49-5.35; p = 0.006), guidewire exchange catheterization (p=0.002), obstructed catheters (RR 2.67; 95% CI 1.63-4.39; p<0.001), and more than 12 days' indwelling time (RR 5.9; 95% CI 3.63-9.41; p<0.001). Multivariate Cox regression identified lower patient weight (HR 2.4; 95% CI 1.11-5.19; p=0.002), guidewire exchange catheterization (HR 2.2; 95% CI 1.07-4.54; p=0.049) and more than 12 days' indwelling time (HR 1.97; 95% CI 0.89-4.36; p=0.089) as significant independent predictors of CRBSI. Factors which protected against infection were the use of povidone-iodine on hubs (HR 0.42; 95% CI 0.19-0.96; p=0.025) and porous versus impermeable dressing (HR 0.41; 95% CI 0.23-0.74; p=0.004). Two children (0.24%) died from endocarditis following catheter-related sepsis due to Stenotrophomonas maltophilia in one case and P. aeruginosa in the other.
conclusionsCatheter-related sepsis is associated with lower patient weight and more than 12 days' indwelling time, but not with the insertion site. Cleaning hubs with povidone-iodine protects from infection.
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