ArticleSocial psychiatry and psychiatric epidemiology2007
Antidepressant utilization in primary care in a Spanish region: impact of generic and reference-based pricing policy (2000-2004).
Article in Social psychiatry and psychiatric epidemiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Pharmaceutical policies: effects of reference pricing, other pricing, and purchasing policies.The Cochrane database of systematic reviews · 2014Pooled it
- [Evolution of the use of antidepressants, anxiolytics and hypnotics in Valencia. Period 2000-2010].Atencion primaria · 2014Observational
- Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications.European journal of clinical pharmacology · 2014Article
- Pitfalls associated with the therapeutic reference pricing practice of asthma medication.BMC pulmonary medicine · 2012Article
- The strategy of combining antidepressants in the treatment of major depression: clinical experience in spanish outpatients.Depression research and treatment · 2011Article
- Effects of reference pricing in pharmaceutical markets: a review.PharmacoEconomics · 2011Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the evolution of antidepressant use in primary care in the Valencian region (Spain) from 2000 to 2004 and to analyze the effects of reference-based price and generic drugs introduction on drug utilization and cost saving.
methodsRetrospective observational study in primary care using sales data collected from antidepressant group (N06A), corresponding to the period 2000-2004. Defined daily dose (DDD)/1000 inhabitants per day were obtained as consumption data. Cost and cost/DDD rate evolution was related to reference price system implantation.
resultsAntidepressant utilization progressively increased by 44.0% from 30.3 DDDs/1000 per day in 2000 to 43.5% in 2004. Selective serotonin reuptake inhibitors (SSRIs) comprised 77% of the total consumption where paroxetine, sertraline and fluoxetine were the most used drugs in 2004. The proportion of relative use and cost of fluoxetine declined after a reference price and the introduction of generic competitors were put into effect in 1999; cost/DDD was reduced by 1.8. Third-generation antidepressants showed a fast rising rate i.e. venlafaxine utilization multiplied by 2.2; this drug with the higher cost/DDD was not subjected to the reference price system. Reduction in citalopram utilization was related to a replacement by its recently marketed enantiomer escitalopram.
conclusionsIn 2004, reference price policy and the implementation of generic drugs reduced the antidepressant cost by DDD. However, antidepressant expenditure increased since 2000 due to a continued growth in consumption (SSRIs and novel agents) and a displacement of prescriptions to drugs that were not included in the reference price policy.
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