ArticleThe EMBO journal2007
Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification.
Article in The EMBO journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma.Oncogenesis · 2022Article
- KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer.Science advances · 2022Article
- GSDME Increases Chemotherapeutic Drug Sensitivity by Inducing Pyroptosis in Retinoblastoma Cells.Oxidative medicine and cellular longevity · 2022Article
- Disrupting the DREAM transcriptional repressor complex induces apolipoprotein overexpression and systemic amyloidosis in mice.The Journal of clinical investigation · 2021Article
- The Role and Clinical Implications of the Retinoblastoma (RB)-E2F Pathway in Gastric Cancer.Frontiers in oncology · 2021Review
- Clinical, Genomic, and Pharmacological Study ofCancers · 2020Article
- Retinoblastoma: Etiology, Modeling, and Treatment.Cancers · 2020Review
- Identification of microRNA-mRNA regulatory networks and pathways related to retinoblastoma across human and mouse.International journal of ophthalmology · 2020Article
- Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence.The Journal of clinical investigation · 2017Article
- Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma.Cancer medicine · 2017Article
- Lessons from Retinoblastoma: Implications for Cancer, Development, Evolution, and Regenerative Medicine.Trends in molecular medicine · 2016Review
- The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency.The Journal of biological chemistry · 2015Article
- Transgenic Models in Retinoblastoma Research.Ocular oncology and pathology · 2015Review
- Revisiting tissue specificity of germline cancer predisposing mutations.Nature reviews. Cancer · 2015Article
- Genetic and Epigenetic Discoveries in Human Retinoblastoma.Critical reviews in oncogenesis · 2015Review
- RB1 gene inactivation by chromothripsis in human retinoblastoma.Oncotarget · 2014Article
- Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting.Cell division · 2013Article
- Animal models in retinoblastoma research.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society · 2013Article
- In vivo animal models for studying brain metastasis: value and limitations.Clinical & experimental metastasis · 2013Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Human retinoblastoma is a pediatric cancer initiated by RB gene mutations in the developing retina. We have examined the origins and progression of retinoblastoma in mouse models of the disease. Retina-specific inactivation of Rb on a p130-/- genetic background led to bilateral retinoblastoma with rapid kinetics, whereas on a p107-/- background Rb mutation caused predominantly unilateral tumors that arose with delayed kinetics and incomplete penetrance. In both models, retinoblastomas arose from cells at the extreme periphery of the murine retina. Furthermore, late retinoblastomas progressed to invade the brain and metastasized to the cervical lymph nodes. Metastatic tumors lacking Rb and p130 exhibited chromosomal changes revealed by representational oligonucleotide microarray analysis including high-level amplification of the N-myc oncogene. N-myc was found amplified in three of 16 metastatic retinoblastomas lacking Rb and p130 as well as in retinoblastomas lacking Rb and p107. N-myc amplification ranged from 6- to 400-fold and correlated with high N-myc-expression levels. These murine models closely resemble human retinoblastoma in their progression and secondary genetic changes, making them ideal tools for further dissection of steps to tumorigenesis and for testing novel therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.