ArticleBlood2007
GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Influence of polyfunctional TbetFrontiers in immunology · 2025Trial
- Effect of vitamin D supplementation on cathelicidin, IFN-γ, IL-4 and Th1/Th2 transcription factors in young healthy females.European journal of clinical nutrition · 2014Trial
- sLeX Expression Delineates Distinct Functional Subsets of Human Blood Central and Effector Memory T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Optimal identification of human conventional and nonconventional (CRTH2The Journal of allergy and clinical immunology · 2020Article
- Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma.The Korean journal of internal medicine · 2020Article
- Age Distribution of Multiple Functionally Relevant Subsets of CD4+ T Cells in Human Blood Using a Standardized and Validated 14-Color EuroFlow Immune Monitoring Tube.Frontiers in immunology · 2020Article
- Article
- Humanized mouse model for assessing the human immune response to xenogeneic and allogeneic decellularized biomaterials.Biomaterials · 2017Article
- Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease.Molecular and cellular pediatrics · 2016Review
- Phosphocholine-containing ligands direct CRP induction of M2 macrophage polarization independent of T cell polarization: Implication for chronic inflammatory states.Immunity, inflammation and disease · 2016Article
- Avidity of human T cell receptor engineered CD4(+) T cells drives T-helper differentiation fate.Cellular immunology · 2016Article
- Interleukin-25 initiates Th2 differentiation of human CD4(+) T cells and influences expression of its own receptor.Immunity, inflammation and disease · 2015Article
- Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans.Aging cell · 2015Article
- Omalizumab for difficult-to-treat dermatological conditions: clinical and immunological features from a retrospective real-life experience.Clinical drug investigation · 2015Article
- Immunologic changes in frail older adults.Translational medicine @ UniSa · 2014Review
- Transcription factor interplay in T helper cell differentiation.Briefings in functional genomics · 2013Review
- T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.Nature communications · 2012Article
- Chemoattractant receptor homologous to the T helper 2 cell (CRTH2) is not expressed in human amniocytes and myocytes.PloS one · 2012Article
- Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
GATA-3 and T-box expressed in T cells (T-bet) play central roles in Th-cell development and function. Consistently, studies in mice document their selective expression in Th1 and Th2 cells, respectively. In contrast, it is not clear whether these genes are regulated in human Th cells. Here we show that T-bet expression is polarized to a comparable degree in human and mouse Th-cell cultures, while only mouse GATA3 is subject to substantial regulation. This did not reflect differential skewing efficiency in human versus mouse cultures, as these contained similar frequencies of IFN-gamma- and IL-4-producing cells. However, GATA-3 was expressed at significantly higher levels in human IL-4-producing cells enriched via capture with monoclonal antibodies (mAbs) against the PGD(2) receptor, CRTH2, the best selective Th2-cell surface marker to date. Along with increased IL-4 and GATA-3, CRTH2(+) Th cells isolated from Th2-skewed cultures or the circulating memory pool exhibited markedly decreased IFN-gamma and T-bet expression. Thus, the human GATA-3 gene is not regulated in response to polarizing signals that are sufficient to direct Th2-specific expression in mouse cells. This postulates the involvement of an additional level of complexity in the regulation of human GATA-3 expression and stresses the existence of nontrivial differences in the regulation of human versus mouse T-cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.