ArticleThe Journal of physiology2007
Bioluminescence imaging of mitochondrial Ca2+ dynamics in soma and neurites of individual adult mouse sympathetic neurons.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Therapeutic Potential of Heterocyclic Compounds Targeting Mitochondrial Calcium Homeostasis and Signaling in Alzheimer's Disease and Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Remodeling of Intracellular CaInternational journal of molecular sciences · 2020Review
- Brain activity regulates loose coupling between mitochondrial and cytosolic CaNature communications · 2019Article
- Mitochondrial CaFEBS letters · 2019Review
- The coupling of plasma membrane calcium entry to calcium uptake by endoplasmic reticulum and mitochondria.The Journal of physiology · 2014Review
- Novel features on the regulation by mitochondria of calcium and secretion transients in chromaffin cells challenged with acetylcholine at 37°C.Physiological reports · 2013Article
- Pre-moxibustion and moxibustion prevent Alzheimer's disease.Neural regeneration research · 2013Article
- Mitochondrial free Ca²⁺ levels and their effects on energy metabolism in Drosophila motor nerve terminals.Biophysical journal · 2013Article
- Mitochondria and chromaffin cell function.Pflugers Archiv : European journal of physiology · 2012Review
- Presynaptic mitochondria in functionally different motor neurons exhibit similar affinities for Ca2+ but exert little influence as Ca2+ buffers at nerve firing rates in situ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease.Frontiers in synaptic neuroscience · 2010Article
- The endoplasmic reticulum of dorsal root ganglion neurons contains functional TRPV1 channels.The Journal of biological chemistry · 2009Article
- Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease.Experimental neurology · 2009Review
- ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP.Pflugers Archiv : European journal of physiology · 2008Article
- Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.PloS one · 2008Article
- Mitochondria and Ca(2+) signaling: old guests, new functions.Pflugers Archiv : European journal of physiology · 2007Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in the cytosolic Ca(2+) concentration ([Ca(2+)](c)) are essential for triggering neurotransmitter release from presynaptic nerve terminals. Calcium-induced Ca(2+) release (CICR) from the endoplasmic reticulum (ER) may amplify the [Ca(2+)](c) signals and facilitate neurotransmitter release in sympathetic neurons. In adrenal chromaffin cells, functional triads are formed by voltage-operated Ca(2+) channels (VOCCs), CICR sites and mitochondria. In fact, mitochondria take up most of the Ca(2+) load entering the cells and are essential for shaping [Ca(2+)](c) signals and exocytosis. Here we have investigated the existence of such functional triads in sympathetic neurons. The mitochondrial Ca(2+) concentration ([Ca(2+)](m)) in soma and neurites of individual mouse superior cervical ganglion (SCG) neurons was monitored by bioluminescence imaging of targeted aequorins. In soma, Ca(2+) entry through VOCCs evoked rapid, near millimolar [Ca(2+)](m) increases in a subpopulation of mitochondria containing about 40% of the aequorin. Caffeine evoked a similar [Ca(2+)](m) increase in a mitochondrial pool containing about 30% of the aequorin and overlapping with the VOCC-sensitive pool. These observations suggest the existence of functional triads similar to the ones described in chromaffin cells. In neurites, mitochondria were able to buffer [Ca(2+)](c) increases resulting from activation of VOCCs but not those mediated by caffeine-induced Ca(2+) release from the ER. The weaker Ca(2+) buffering by mitochondria in neurites could contribute to facilitate Ca(2+)-induced exocytosis at the presynaptic sites.
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