ArticleThorax2007
Survey of acute renal failure in patients with cystic fibrosis in the UK.
Article in Thorax, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06595420 (Kidney Function in People With Cystic Fibrosis in the Era of HEMT), which is not on this map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Kidney Function in People With Cystic Fibrosis in the Era of HEMT
Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis.The Cochrane database of systematic reviews · 2025Pooled it
- Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis.The Cochrane database of systematic reviews · 2019Pooled it
- Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis.The Cochrane database of systematic reviews · 2017Pooled it
- Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis.The Cochrane database of systematic reviews · 2015Pooled it
- Population pharmacokinetics of tobramycin in patients with and without cystic fibrosis.Clinical pharmacokinetics · 2013Pooled it
- The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2016Trial
- Risk factors for acute kidney injury during aminoglycoside therapy in patients with cystic fibrosis.Pediatric nephrology (Berlin, Germany) · 2015Trial
- Pharmacokinetics and pharmacodynamics of once-daily administration of intravenous tobramycin in adult patients with cystic fibrosis hospitalized for an acute pulmonary exacerbation.Antimicrobial agents and chemotherapy · 2013Trial
- Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis.British journal of clinical pharmacology · 2026Review
- Cystic fibrosis-related kidney disease-emerging morbidity and disease modifier.Pediatric nephrology (Berlin, Germany) · 2025Review
- Kidney and combined kidney and pancreas transplantation may be under-utilized in cystic fibrosis.Frontiers in transplantation · 2022Article
- [Abdominal manifestations in cystic fibrosis : Clinical review].Der Radiologe · 2020Review
- Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin.Scientific reports · 2018Observational
- Study design considerations for the Standardized Treatment of Pulmonary Exacerbations 2 (STOP2): A trial to compare intravenous antibiotic treatment durations in CF.Contemporary clinical trials · 2018Article
- Aminoglycoside-induced nephrotoxicity in children.Pediatric nephrology (Berlin, Germany) · 2017Review
- Glomerular and Tubular Renal Function after Repeated Once-Daily Tobramycin Courses in Cystic Fibrosis Patients.Pulmonary medicine · 2017Article
- Bayesian Estimation of Tobramycin Exposure in Patients with Cystic Fibrosis.Antimicrobial agents and chemotherapy · 2016Article
- Nodular glomerulosclerosis in a patient with cystic fibrosis, but not diabetes mellitus: A paediatric case.Respiratory medicine case reports · 2016Article
- Renal diseases in adults with cystic fibrosis: a 40 year single centre experience.Journal of nephrology · 2015Article
- Daily serum creatinine monitoring promotes earlier detection of acute kidney injury in children and adolescents with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere has been a recent increase in the number of reported cases of acute renal failure (ARF) in cystic fibrosis (CF). A study was undertaken to determine the incidence risk of ARF in patients with CF in the UK and to identify possible aetiological factors.
methodsAll doctors working at UK CF centres were asked if they had been involved with the management of a patient with CF who had developed ARF. Those responding positively were asked to request informed consent for entry into the study and the patient's case notes were then reviewed. The analysis was restricted to patients developing ARF between 1997 and 2004. A second questionnaire sought information on aminoglycoside prescribing practice.
resultsResponses were received from 55 of 56 centres with 64 reports, 9 of which were duplicates, leaving 55 cases. Consent was obtained for data extraction in 26 cases, of which 24 fitted the criteria for ARF (verified data). Median age at presentation with ARF was 9.7 years (range 0.4-31.8) and 12 cases were male. The incidence risk of ARF was 4.6 (verified data) to 10.5 cases (all data)/10,000 CF patients/year. In 21 cases (88%) an aminoglycoside was prescribed at onset of ARF or in the preceding week; 16 (76%) of those receiving an aminoglycoside had gentamicin. A renal biopsy was performed in 7 cases and histological examination revealed acute tubular necrosis in 6, all of whom had received gentamicin. Renal dialysis was required in 13 cases (54%). Complete recovery was seen in 22/24 patients (92%).
conclusionsARF is increasingly being recognised in patients with CF. There is significant morbidity with most patients requiring dialysis. This study implicates intravenous aminoglycosides, particularly gentamicin, in the aetiology of ARF in CF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.