ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Long-term sensitization training produces spike narrowing in Aplysia sensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Transcriptional changes before and after forgetting of a long-term sensitization memory in Aplysia californica.Neurobiology of learning and memory · 2018Article
- Transcriptional correlates of memory maintenance following long-term sensitization ofLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Nonassociative learning in invertebrates.Cold Spring Harbor perspectives in biology · 2015Review
- Characterization of the rapid transcriptional response to long-term sensitization training in Aplysia californica.Neurobiology of learning and memory · 2014Article
- Immediate and persistent transcriptional correlates of long-term sensitization training at different CNS loci in Aplysia californica.PloS one · 2014Article
- Transcriptional changes following long-term sensitization training and in vivo serotonin exposure in Aplysia californica.PloS one · 2012Article
- Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- More than synaptic plasticity: role of nonsynaptic plasticity in learning and memory.Trends in neurosciences · 2010Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Both short- and long-term sensitization of withdrawal reflexes of Aplysia are attributable at least in part to facilitation of the sensorimotor synapse. Previously, short-term synaptic facilitation has been associated with spike broadening and no change in temporal dynamics of burst transmission. In the present study, we examined whether long-term sensitization (LTS) is also associated with spike broadening and whether long-term synaptic facilitation is accompanied by changes in temporal dynamics. The results indicate that the temporal dynamics of the sensorimotor synapse are preserved after long-term facilitation. However, in contrast to short-term sensitization, LTS was accompanied by spike narrowing. The spike narrowing was observed both in centrally triggered spikes in isolated ganglia and in peripherally triggered spikes in reduced tail preparations. In addition, in reduced tail preparations, fewer spike failures in the afferent discharge of sensory neurons occurred in response to tail stimulation after ipsilateral LTS. Collectively, the results reveal that long-term sensitization affects the spike waveform of sensory neurons and enhances the sensory neuron responses to peripheral stimuli, but does not modify the synaptic dynamics of homosynaptic depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.