ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Nanodomains of single Ca2+ channels contribute to action potential repolarization in cortical neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 74 citations in OpenAlex.
- Lipid trapping slows ball-and-chain inactivation in a calcium-activated potassium channel.Nature communications · 2026Article
- On the molecular basis of enduring memory in neurons, and cell fate in fibroblasts.Nucleic acids research · 2026Review
- Unreliable homeostatic action potential broadening in cultured dissociated neurons.bioRxiv : the preprint server for biology · 2025Article
- Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies.Frontiers in integrative neuroscience · 2024Review
- Large conductance voltage-and calcium-activated KFrontiers in pharmacology · 2024Review
- Physiology of intracellular calcium buffering.Physiological reviews · 2023Review
- CaInternational journal of molecular sciences · 2023Review
- Article
- BK Channel Regulation of Afterpotentials and Burst Firing in Cerebellar Purkinje Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Bioluminescent Sensors for CaFrontiers in bioengineering and biotechnology · 2021Article
- BK Channels Are Activated by Functional Coupling With L-Type CaFrontiers in insect science · 2021Article
- Structural and Functional Coupling of Calcium-Activated BK Channels and Calcium-Permeable Channels Within Nanodomain Signaling Complexes.Frontiers in physiology · 2021Review
- Upregulation of Beta4 subunit of BKMolecular brain · 2020Article
- Comparative gain-of-function effects of theJournal of neurophysiology · 2020Article
- From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells.International journal of molecular sciences · 2019Article
- Developmental Synaptic Changes at the Transient Olivocochlear-Inner Hair Cell Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Physiological Roles and Therapeutic Potential of CaFrontiers in molecular neuroscience · 2018Review
- Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Physiological reviews · 2018Review
- Article
- Concise Whole-Cell Modeling of BKBiophysical journal · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The precise shape of action potentials in cortical neurons is a key determinant of action potential-dependent Ca2+ influx, as well as of neuronal signaling, on a millisecond scale. In cortical neurons, Ca2+-sensitive K+ channels, or BK channels (BKChs), are crucial for action potential termination, but the precise functional interplay between Ca2+ channels and BKChs has remained unclear. In this study, we investigate the mechanisms allowing for rapid and reliable activation of BKChs by single action potentials in hippocampal granule cells and the impact of endogenous Ca2+ buffers. We find that BKChs are operated by nanodomains of single Ca2+ channels. Using a novel approach based on a linear approximation of buffered Ca2+ diffusion in microdomains, we quantitatively analyze the prolongation of action potentials by the Ca2+ chelator BAPTA. This analysis allowed us to estimate that the mean diffusional distance for Ca2+ ions from a Ca2+ channel to a BKCh is approximately 13 nm. This surprisingly short diffusional distance cannot be explained by a random distribution of Ca2+ channels and renders the activation of BKChs insensitive to the relatively high concentrations of endogenous Ca2+ buffers in hippocampal neurons. These data suggest that tight colocalization of the two types of channels permits hippocampal neurons to regulate global Ca2+ signals by a high cytoplasmic Ca2+ buffer capacity without affecting the fast and brief activation of BKChs required for proper repolarization of action potentials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.