ArticleDrugs & aging2007
Effects of statins on cognitive function in patients with Alzheimer's disease in galantamine clinical trials.
Article in Drugs & aging, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Impact on cognitive function-are all statins the same?Current atherosclerosis reports · 2015Pooled it
- Treatment of vascular risk factors in patients with a diagnosis of Alzheimer's disease: a systematic review.BMC medicine · 2014Pooled it
- Statins for the treatment of dementia.The Cochrane database of systematic reviews · 2014Pooled it
- A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease.Neurology · 2011Trial
- Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults.Journal of the American College of Cardiology · 2021Observational
- Overview the effect of statin therapy on dementia risk, cognitive changes and its pathologic change: a systematic review and meta-analysis.Annals of translational medicine · 2018Article
- Traditional Korean East Asian medicines and herbal formulations for cognitive impairment.Molecules (Basel, Switzerland) · 2013Review
- Secondary stroke prevention strategies for the oldest patients: possibilities and challenges.Drugs & aging · 2009Review
- Progress update: Pharmacological treatment of Alzheimer's disease.Neuropsychiatric disease and treatment · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveA number of reports have been published on the possible involvement of changes in brain cholesterol metabolism in the origin of Alzheimer's disease (AD) and the potential for influencing these changes by administration of HMG-CoA reductase inhibitors ('statins'). The aim of this study was to evaluate a potential association between use of statins and maintenance of cognitive function in patients with AD in galantamine clinical trials.
methodA post hoc analysis was conducted on data pooled from three double-blind, placebo-controlled, clinical trials of galantamine in patients with AD. Patients were divided into four treatment groups: statin plus galantamine (n = 42), statin alone (n = 50), galantamine alone (n = 614) or neither galantamine nor statin (n = 619).
resultsGalantamine was associated with a significant beneficial effect on cognitive status (p < 0.001). The association of use of statins with changes in cognitive status was not significant (p = 0.083). There was no significant interaction between the effects on cognition of statins and galantamine (p = 0.183) and no statistically significant changes in adverse effect rates were observed.
conclusionThese findings suggest the need for larger long-term trials to confirm or refute possible effects of statins on cognitive function and the potential interaction of statins with acetylcholinesterase inhibitors in the treatment of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.