Evidence map›Paper›PMID 1723075›Full record

ArticleJournal of clinical microbiology1991

Homotypic and heterotypic serological responses to rotavirus neutralization epitopes in immunologically naive and experienced animals.

D R Snodgrass, T A Fitzgerald, I Campbell, G F Browning, F M Scott, Y Hoshino, R C Davies

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

D R SnodgrassMoredun Research Institute, Edinburgh, Scotland.
T A Fitzgerald
I Campbell
G F Browning
F M Scott
Y Hoshino
R C Davies
Moredun Research Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gnotobiotic or specific-pathogen-free animals with no previous exposure to rotavirus were vaccinated with strain UK, serotype G6. The highest serological response was to homologous virus; significant but lower responses occurred to viruses with either VP4 or VP7 related to that of vaccine virus; responses to other viruses were of low titer or infrequent. Adult cows vaccinated with UK virus produced increased titers of antibody to all rotavirus serotypes. The increases in titer to homologous virus and to other natural and reassortant viruses sharing VP7 with the vaccine virus were significantly higher than those to all other viruses. These results suggest the presence of common epitopes which are not well recognized in primary infections.

Indexed as

Antigens, ViralCapsid ProteinsAnimalsAntibodies, ViralCapsidCattleEpitopesGerm-Free LifeNeutralization TestsRotavirusRotavirus InfectionsSheepViral VaccinesAntibodies, ViralAntigens, ViralCapsid ProteinsEpitopesViral VaccinesVP4 protein, RotavirusVP7 protein, Rotavirus

Identifiers

PMID1723075
PMCPMC270403
OpenAlexW1741438911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.