ArticleInternational journal of cancer2007
Effects of base excision repair gene polymorphisms on pancreatic cancer survival.
Article in International journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of Diabetes Mellitus on Survival in Patients with Pancreatic Cancer: A Systematic Review and Meta-analysis.Scientific reports · 2015Pooled it
- Lack of association of XRCC1 rs1799782 genetic polymorphism with risk of pancreatic cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- MRI-based radiogenomics analysis for predicting prognosis and XRCC1 gene polymorphism in pancreatic ductal adenocarcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Association of hOGG1 Ser326Cys, ITGA2 C807T, TNF-A -308G>A and XPD Lys751Gln polymorphisms with the survival of Malaysian NPC patients.PloS one · 2018Article
- Is it time to split strategies to treat homologous recombinant deficiency in pancreas cancer?Journal of gastrointestinal oncology · 2016Review
- Association between OGG1 gene single nucleotide polymorphisms and risk of pancreatic cancer in Chinese.Medical oncology (Northwood, London, England) · 2014Article
- Association of XRCC1 gene single nucleotide polymorphisms and susceptibility to pancreatic cancer in Chinese.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Genome-wide analysis of the role of copy-number variation in pancreatic cancer risk.Frontiers in genetics · 2014Article
- Association between single-nucleotide polymorphisms of OGG1 gene and pancreatic cancer risk in Chinese Han population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- A replication study and genome-wide scan of single-nucleotide polymorphisms associated with pancreatic cancer risk and overall survival.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Systemic therapies for pancreatic cancer--the role of pharmacogenetics.Current drug targets · 2012Review
- Targeting DNA polymerase ß for therapeutic intervention.Current molecular pharmacology · 2012Review
- Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer.Pancreas · 2011Article
- An overview of genetic polymorphisms and pancreatic cancer risk in molecular epidemiologic studies.Journal of epidemiology · 2011Review
- Article
- Population-specific variation in haplotype composition and heterozygosity at the POLB locus.DNA repair · 2009Article
- Basic principles and technologies for deciphering the genetic map of cancer.World journal of surgery · 2009Review
- SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms.Bioinformatics (Oxford, England) · 2009Article
- DNA repair gene polymorphisms and risk of pancreatic cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- DNA repair proteins as molecular targets for cancer therapeutics.Anti-cancer agents in medicinal chemistry · 2008Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
To explore the association between single nucleotide polymorphisms of DNA repair genes and overall survival of patients with pancreatic cancer, we conducted a study in 378 cases of pancreatic adenocarcinoma who were treated at The University of Texas M. D. Anderson Cancer Center between February 1999 and October 2004 and were followed up to April 2006. Genotypes were determined using genomic DNA and the MassCode method. Overall survival was analyzed using the Kaplan-Meier plot, log-rank test and Cox regression. We observed a strong effect of the POLB A165G and T2133C genotypes on overall survival. The median survival time (MST) was 35.7 months for patients carrying at least 1 of the 2 homozygous variant POLB GG or CC genotypes, compared with 14.8 months for those carrying the AA/AG or TT/TC genotypes (p = 0.02, log rank test). The homozygous variants of hOGG1 G2657A, APEX1 D148E and XRCC1 R194W polymorphisms all showed a weak but significant effect on overall survival as demonstrated by either log rank test or multivariate COX regression after adjusting for other potential confounders. In combined genotype analysis, a predominant effect of the POLB homozygous variants on survival was observed. When POLB was not included in the model, a slightly better survival was observed among those carrying none of the adverse genotypes than those carrying at least one of the adverse genotypes. These observations suggest that polymorphisms of base excision repair genes significantly affect the clinical outcome of patients with pancreatic cancer. These observations need to be confirmed in a larger study of homogenous patient population.
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