ArticleMolecular biology of the cell2007
Genetic control of fusion pore expansion in the epidermis of Caenorhabditis elegans.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Review
- Pleomorphism in Biological Units of Life: Morphological Heterogeneity in Cells Does Not Translate Uniformly to Subcellular Components.ACS omega · 2024Article
- Malaria parasites utilize two essential plasma membrane fusogens for gamete fertilization.Cellular and molecular life sciences : CMLS · 2022Article
- Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins.Nature communications · 2022Article
- YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion.Nature communications · 2021Article
- From wound response to repair - lessons from C. elegans.Cell regeneration (London, England) · 2021Review
- How cells fuse.The Journal of cell biology · 2019Review
- Endocytosis regulates membrane localization and function of the fusogen EFF-1.Small GTPases · 2017Review
- Article
- Article
- RAB-5- and DYNAMIN-1-Mediated Endocytosis of EFF-1 Fusogen Controls Cell-Cell Fusion.Cell reports · 2016Article
- The EFF-1A Cytoplasmic Domain Influences Hypodermal Cell Fusions in C. elegans But Is Not Dependent on 14-3-3 Proteins.PloS one · 2016Article
- Genetic basis of cell-cell fusion mechanisms.Trends in genetics : TIG · 2013Review
- Finding a niche for seam cells?Worm · 2012Article
- Myoblast fusion: lessons from flies and mice.Development (Cambridge, England) · 2012Review
- The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate.PLoS genetics · 2011Article
- Inner/Outer nuclear membrane fusion in nuclear pore assembly: biochemical demonstration and molecular analysis.Molecular biology of the cell · 2010Article
- The stratified syncytium of the vertebrate lens.Journal of cell science · 2009Article
- Enhanced fusion pore expansion mediated by the trans-acting Endodomain of the reovirus FAST proteins.PLoS pathogens · 2009Article
- Fusion-pore expansion during syncytium formation is restricted by an actin network.Journal of cell science · 2008Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Developmental cell fusion is found in germlines, muscles, bones, placentae, and stem cells. In Caenorhabditis elegans 300 somatic cells fuse during development. Although there is extensive information on the early intermediates of viral-induced and intracellular membrane fusion, little is known about late stages in membrane fusion. To dissect the pathway of cell fusion in C. elegans embryos, we use genetic and kinetic analyses using live-confocal and electron microscopy. We simultaneously monitor the rates of multiple cell fusions in developing embryos and find kinetically distinct stages of initiation and completion of membrane fusion in the epidermis. The stages of cell fusion are differentially blocked or retarded in eff-1 and idf-1 mutants. We generate kinetic cell fusion maps for embryos grown at different temperatures. Different sides of the same cell differ in their fusogenicity: the left and right membrane domains are fusion-incompetent, whereas the anterior and posterior membrane domains fuse with autonomous kinetics in embryos. All but one cell pair can initiate the formation of the largest syncytium. The first cell fusion does not trigger a wave of orderly fusions in either direction. Ultrastructural studies show that epidermal syncytiogenesis require eff-1 activities to initiate and expand membrane merger.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.