ArticleProceedings of the National Academy of Sciences of the United States of America2007
A proposal for robust temperature compensation of circadian rhythms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation.NPJ systems biology and applications · 2025Article
- Waveform distortion for temperature compensation and synchronization in circadian rhythms: An approach based on the renormalization group method.PLoS computational biology · 2025Article
- A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Temperature compensation through kinetic regulation in biochemical oscillators.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Temperature-driven coordination of circadian transcriptional regulation.PLoS computational biology · 2024Article
- Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock.PLoS biology · 2023Article
- Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms.NPJ systems biology and applications · 2023Article
- Role of the reaction-structure coupling in temperature compensation of the KaiABC circadian rhythm.PLoS computational biology · 2022Article
- Temperature Controls Onset and Period of NF-Frontiers in cell and developmental biology · 2022Article
- Article
- A mathematical model of circadian rhythms and dopamine.Theoretical biology & medical modelling · 2021Article
- Non-sinusoidal Waveform in Temperature-Compensated Circadian Oscillations.Biophysical journal · 2019Article
- Article
- Temperature-amplitude coupling for stable biological rhythms at different temperatures.PLoS computational biology · 2017Article
- Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock.Frontiers in neurology · 2017Review
- Robust network topologies for generating oscillations with temperature-independent periods.PloS one · 2017Article
- Temperature-Robust Neural Function from Activity-Dependent Ion Channel Regulation.Current biology : CB · 2016Article
- Protein sequestration versus Hill-type repression in circadian clock models.IET systems biology · 2016Review
- The effects of time-varying temperature on delays in genetic networks.SIAM journal on applied dynamical systems · 2016Article
- Temperature compensation and temperature sensation in the circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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3 authors.
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Abstract
The internal circadian rhythms of cells and organisms coordinate their physiological properties to the prevailing 24-h cycle of light and dark on earth. The mechanisms generating circadian rhythms have four defining characteristics: they oscillate endogenously with period close to 24 h, entrain to external signals, suffer phase shifts by aberrant pulses of light or temperature, and compensate for changes in temperature over a range of 10 degrees C or more. Most theoretical descriptions of circadian rhythms propose that the underlying mechanism generates a stable limit cycle oscillation (in constant darkness or dim light), because limit cycles quite naturally possess the first three defining properties of circadian rhythms. On the other hand, the period of a limit cycle oscillator is typically very sensitive to kinetic rate constants, which increase markedly with temperature. Temperature compensation is therefore not a general property of limit cycle oscillations but must be imposed by some delicate balance of temperature dependent effects. However, "delicate balances" are unlikely to be robust to mutations. On the other hand, if circadian rhythms arise from a mechanism that concentrates sensitivity into a few rate constants, then the "balancing act" is likely to be more robust and evolvable. We propose a switch-like mechanism for circadian rhythms that concentrates period sensitivity in just two parameters, by forcing the system to alternate between a stable steady state and a stable limit cycle.
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