Evidence map›Paper›PMID 17229744›Full record

Trial reportJournal of neurology, neurosurgery, and psychiatry2007

Cueing training in the home improves gait-related mobility in Parkinson's disease: the RESCUE trial.

A Nieuwboer, G Kwakkel, L Rochester, D Jones, E van Wegen, A M Willems, F Chavret, V Hetherington, K Baker, I Lim

Erratum issued 6 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurology, neurosurgery, and psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 6 registered trials, which are not on this map. Cited by 284 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 18 pooled it
86.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01076712 naunknown statusnot on this mapstarted 2010, after this paper: background citation

The Effectiveness of Physiotherapy Interventions in Patients With Parkinson's Disease, a Randomized Controlled Trial

TypeinterventionalSponsorQueen Elizabeth Hospital, Hong KongRan2010 to 2012Enrolled112ConditionsParkinson DiseaseArmsPhysiotherapy Interventions, Education Classes
NCT01246700 naunknown statusnot on this mapstarted 2008, after this paper: background citation

Sensory Attention Focused Exercise in Parkinson's Disease: A Randomized Double-Crossover Trial.

TypeinterventionalSponsorSun Life Financial Movement Disorders Research and Rehabilitation CentreRan2008 to 2010Enrolled76ConditionsParkinson's DiseaseArmsSensory Attention Focused Exercise (SAFEx)
NCT02438124 naunknown statusnot on this mapstarted 2014, after this paper: background citation

Rhythmic Auditory Stimulation Optimalization for Gait Improvement in Parkinson's

TypeinterventionalSponsorUniversity Hospital, MontpellierRan2014 to 2016Enrolled80ConditionsParkinson's DiseaseArmsNeuropsychological evaluation
NCT06174948 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Use of the CUE1/CUE1+ Device in People With Idiopathic Parkinson's Disease and Related Disorders: A Feasibility Study

TypeinterventionalSponsorQueen Mary University of LondonRan2024 to 2025Enrolled70ConditionsParkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Different Types of Tremor Including Essential Tremor, DystoniaArmsCUE1 non-invasive device, CUE1+ device active vs sham CUE1+ device
NCT06590987 nacompletednot on this mapstarted 2024, after this paper: background citation

Cueing-assisted Gamified Augmented-reality Gait-and-balance Rehabilitation at Home for People With Parkinson's Disease: Protocol of a Pragmatic Randomized Controlled Trial Implemented in the Clinical Pathway

TypeinterventionalSponsorVU University of AmsterdamRan2024 to 2025Enrolled100ConditionsParkinson DiseaseArmsStrolll AR
NCT07584993 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

CuePD in the Home: Retraining Gait in Parkinson's Disease Via a Personalised App

TypeinterventionalSponsorNorthumbria UniversityRan2026 to 2027Enrolled40ConditionsPARKINSON DISEASE (Disorder)ArmsCuePD, Control material
3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 18 syntheses or guidelines pooled it, 842 citations in OpenAlex.

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  9. Interventions for preventing falls in Parkinson's disease.The Cochrane database of systematic reviews · 2022
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224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

A NieuwboerDepartment of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit, Leuven, Belgium. alice.nieuwboer@faber.kuleuven.be
G Kwakkel
L Rochester
D Jones
E van Wegen
A M Willems
F Chavret
V Hetherington
K Baker
I Lim
Northumbria University · GBKU Leuven · BEVrije Universiteit Amsterdam · NLPain and Rehabilitation Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesGait and mobility problems are difficult to treat in people with Parkinson's disease. The Rehabilitation in Parkinson's Disease: Strategies for Cueing (RESCUE) trial investigated the effects of a home physiotherapy programme based on rhythmical cueing on gait and gait-related activity.

methodsA single-blind randomised crossover trial was set up, including 153 patients with Parkinson's disease aged between 41 and 80 years and in Hoehn and Yahr stage II-IV. Subjects allocated to early intervention (n = 76) received a 3-week home cueing programme using a prototype cueing device, followed by 3 weeks without training. Patients allocated to late intervention (n = 77) underwent the same intervention and control period in reverse order. After the initial 6 weeks, both groups had a 6-week follow-up without training. Posture and gait scores (PG scores) measured at 3, 6 and 12 weeks by blinded testers were the primary outcome measure. Secondary outcomes included specific measures on gait, freezing and balance, functional activities, quality of life and carer strain.

resultsSmall but significant improvements were found after intervention of 4.2% on the PG scores (p = 0.005). Severity of freezing was reduced by 5.5% in freezers only (p = 0.007). Gait speed (p = 0.005), step length (p<0.001) and timed balance tests (p = 0.003) improved in the full cohort. Other than a greater confidence to carry out functional activities (Falls Efficacy Scale, p = 0.04), no carry-over effects were observed in functional and quality of life domains. Effects of intervention had reduced considerably at 6-week follow-up.

conclusionsCueing training in the home has specific effects on gait, freezing and balance. The decline in effectiveness of intervention effects underscores the need for permanent cueing devices and follow-up treatment. Cueing training may be a useful therapeutic adjunct to the overall management of gait disturbance in Parkinson's disease.

Indexed as

Exercise TherapyAgedAged, 80 and overCaregiversCross-Over StudiesFemaleGait Disorders, NeurologicHumansMaleMiddle AgedOutpatientsParkinson DiseasePostural BalanceQuality of LifeSingle-Blind MethodTreatment Outcome

Identifiers

PMID17229744
PMCPMC2077658
OpenAlexW2123171587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.