ArticleJournal of virology2007
Formation of a multiple protein complex on the adenovirus packaging sequence by the IVa2 protein.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Mysteries of adenovirus packaging.Journal of virology · 2025Review
- Stepwise virus assembly in the cell nucleus revealed by spatiotemporal click chemistry of DNA replication.Science advances · 2024Article
- Development of monoclonal antibodies targeting the conserved fragment of hexon protein to detect different serotypes of human adenovirus.Microbiology spectrum · 2024Article
- Adenovirus Core Proteins: Structure and Function.Viruses · 2021Review
- Anti-adenoviral Artificial MicroRNAs Expressed from AAV9 Vectors Inhibit Human Adenovirus Infection in Immunosuppressed Syrian Hamsters.Molecular therapy. Nucleic acids · 2017Article
- Adenoviral E4 34K protein interacts with virus packaging components and may serve as the putative portal.Scientific reports · 2017Article
- Development of Potent Antiviral Drugs Inspired by Viral Hexameric DNA-Packaging Motors with Revolving Mechanism.Journal of virology · 2016Review
- Components of Adenovirus Genome Packaging.Frontiers in microbiology · 2016Review
- Adenoviral L4 33K forms ring-like oligomers and stimulates ATPase activity of IVa2: implications in viral genome packaging.Frontiers in microbiology · 2015Article
- Identification and characterization of a DNA binding domain on the adenovirus IVa2 protein.Virology · 2012Article
- The adenovirus L4-22K protein is multifunctional and is an integral component of crucial aspects of infection.Journal of virology · 2012Article
- Adenovirus structural protein IIIa is involved in the serotype specificity of viral DNA packaging.Journal of virology · 2011Article
- Characterization of Empty adenovirus particles assembled in the absence of a functional adenovirus IVa2 protein.Journal of virology · 2011Article
- Adenovirus IVa2 protein binds ATP.Journal of virology · 2008Article
- Presence of the adenovirus IVa2 protein at a single vertex of the mature virion.Journal of virology · 2008Article
- Ternary complex formation on the adenovirus packaging sequence by the IVa2 and L4 22-kilodalton proteins.Journal of virology · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
During adenovirus virion assembly, the packaging sequence mediates the encapsidation of the viral genome. This sequence is composed of seven functional units, termed A repeats. Recent evidence suggests that the adenovirus IVa2 protein binds the packaging sequence and is involved in packaging of the genome. Study of the IVa2-packaging sequence interaction has been hindered by difficulty in purifying the protein produced in virus-infected cells or by recombinant techniques. We report the first purification of a recombinant untagged version of the adenovirus IVa2 protein and characterize its binding to the packaging sequence in vitro. Our data indicate that there is more than one IVa2 binding site within the packaging sequence and that IVa2 binding to DNA requires the A-repeat consensus, 5'-TTTG-(N(8))-CG-3'. Furthermore, we present evidence that IVa2 forms a multimeric complex on the packaging sequence. These data support a model in which adenovirus DNA packaging occurs via the formation of a IVa2 multiprotein complex on the packaging sequence.
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