ArticleJournal of anatomy2007
Insights into the gyrification of developing ferret brain by magnetic resonance imaging.
Article in Journal of anatomy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Ferrets and genetically modified ferrets as model organisms in biomedical research: a review.Frontiers in genome editing · 2026Review
- Investigation of the mechanisms underlying the development and evolution of the mammalian cerebrum using gyrencephalic ferrets.Frontiers in cell and developmental biology · 2026Review
- Article
- Astrocytes in white matter respond to tensile cues during cortical folding: a numerical study.bioRxiv : the preprint server for biology · 2025Article
- Quantifying the Timing of Gyral and Sulcal Formation Relative to Growth in the Ferret Cerebral Cortex.Developmental neuroscience · 2025Article
- Behavioral assessment of well-being in the naïve laboratory ferret (Mustela putorius furo).Scientific reports · 2024Article
- Orchestrated neuronal migration and cortical folding: A computational and experimental study.PLoS computational biology · 2022Article
- Investigation of the Mechanisms Underlying the Development and Evolution of the Cerebral Cortex Using Gyrencephalic Ferrets.Frontiers in cell and developmental biology · 2022Review
- Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms.Frontiers in psychiatry · 2022Article
- Programmed and self-organized flow of information during morphogenesis.Nature reviews. Molecular cell biology · 2021Review
- The Heritability of Cortical Folding: Evidence from the Human Connectome Project.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- The Ferret as a Model System for Neocortex Development and Evolution.Frontiers in cell and developmental biology · 2021Review
- On folding morphogenesis, a mechanical problem.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Deconstructing cortical folding: genetic, cellular and mechanical determinants.Nature reviews. Neuroscience · 2019Review
- The Brain Anatomy of the Brown Bear (Carnivora,Frontiers in neuroanatomy · 2019Article
- Comparison between diffusion MRI tractography and histological tract-tracing of cortico-cortical structural connectivity in the ferret brain.Network neuroscience (Cambridge, Mass.) · 2019Article
- Mechanics of cortical folding: stress, growth and stability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Denser Growing Fiber Connections Induce 3-hinge Gyral Folding.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- How Cells Fold the Cerebral Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Early Development of Network Oscillations in the Ferret Visual Cortex.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The developmental mechanisms underlying the formation of human cortical convolutions (gyri and sulci) remain largely unknown. Genetic causes of lissencephaly (literally 'smooth brain') would imply that disorders in neuronal migration cause the loss of cortical convolutions. However, prior studies have suggested that loss of sulci and gyri can also arise from impaired proliferation, disrupted lamination and loss of intracortical connections. To gain further insight into the mechanisms underlying the formation of cortical convolutions, we examined the progressive brain development of the gyrencephalic ferret. In this study, we used magnetic resonance imaging to follow the temporal and spatial pattern of neuronal migration, proliferation and differentiation in relation to the onset and development of cortical convolutions. In this manner, we demonstrate that the onset of gyrification begins largely after completion of neuronal proliferation and migration. Gyrification occurs in a lateral to medial gradient, during the period of most rapid cerebral cortical growth. Cortical folding is also largely complete prior to myelination of the underlying cortical axons. These observations are consistent with gyrification arising secondary to cortical processes involving neuronal differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.